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Table 3 The effects of ambient respiratory virus on incident RA in subgroups of patients

From: Respiratory viral infections and the risk of rheumatoid arthritis

Subgroup Percent change in incident RA per 1-unit change in the detection rate of virusa 95% CI P value
Sex
 Men
  Parainfluenza virus at lag1–7w 8.24 1.34, 15.61 .019
  Corona virus at lag1–6w 0.20 − 9.77, 11.28 .971
  Metapneumovirus at lag1–6w − 5.11 − 58.96, 75.59 .659
 Women
  Parainfluenza virus at lag1–7w 3.82 0.18, 7.59 .040
  Corona virus at lag1–6w 12.11 5.87, 18.71 < .001
  Metapneumovirus at lag1–6w 67.4 13.04, 147.88 < .001
Age
 < 40 years
  Parainfluenza virus at lag1–7w 10.02 0.73, 20.17 .034
  Corona virus at lag1–6w 7.97 − 6.31, 24.43 .289
  Metapneumovirus at lag1–6w 45.89 − 43.27, 275.18 .433
 40–59 years
  Parainfluenza virus at lag1–7w − 0.11 − 4.38, 4.35 .962
  Corona virus at lag1–6w 5.64 − 1.50, 13.3 .124
  Metapneumovirus at lag1–6w 5.52 − 34.93, 71.09 .828
 ≥ 60 years
  Parainfluenza virus at lag1–7w 10.66 4.96, 16.67 < .001
  Corona virus at lag1–6w 14.64 5.41, 24.67 .001
  Metapneumovirus at lag1–6w 118.19 22.19, 289.61 .008
Previous respiratory disease
 Without respiratory disease
  Parainfluenza virus at lag1–7w 4.48 0.26, 8.87 .037
  Corona virus at lag1–6w 10.61 3.58, 18.11 .003
  Metapneumovirus at lag1–6w 23.87 − 21.09, 94.47 .352
 With respiratory disease
  Parainfluenza virus at lag1–7w 5.66 0.61, 10.97 .028
  Corona virus at lag1–6w 6.72 − 1.43, 15.53 .108
  Metapneumovirus at lag1–6w 79.18 4.52, 207.16 .034
  1. The moving average lag up to 8 lag weeks (lag1–8) was used in the analysis. For example, “lag1–8” refers to a moving average lag model for respiratory viral infections over the previous 8 weeks
  2. CI confidence interval
  3. aRelative risk adjusted for mean particulate matter < 10 μg/m3 in aerodynamic diameter, ozone, temperature, humidity, amount of solar exposure, and seasonality