Chondropathies | Genes | TWAS | mRNA expression | ||
---|---|---|---|---|---|
Tissue | P TWAS | FC | P mRNA | ||
Knee OA | NSA2 | MS/YBL | 2.47 × 10−4/ 3.30 × 10− 4 | − 2.16 | 2.12 × 10− 2 |
CSF1R | YBL | 3.95 × 10−4 | 3.47 | 2.83 × 10−2 | |
MSC | YBL | 9.51 × 10−4 | 4.41 | 2.03 × 10−2 | |
CDK5R1 | YBL | 1.22 × 10−3 | 2.24 | 4.71 × 10−2 | |
MMP24 | MS | 1.49 × 10−3 | 2.41 | 2.64 × 10−2 | |
ARMC1 | MS/ YBL | 1.62 × 10−3/ 8.76 × 10− 3 | − 2.64 | 4.43 × 10− 2 | |
NCK1 | YBL | 1.75 × 10−3 | − 2.26 | 4.73 × 10−2 | |
NME6 | MS/YBL | 9.93 × 10−3/ 1.75 × 10− 3 | − 2.93 | 2.22 × 10− 3 | |
DDX20 | YBL | 1.79 × 10−3 | 2.69 | 1.15 × 10−2 | |
SCARB1 | YBL | 2.55 × 10−3 | − 3.27 | 6.75 × 10−3 | |
CT | SRGN | YBL | 1.46 × 10−3 | 3.36 | 4.18 × 10−2 |
ETS1 | YBL | 3.07 × 10−3 | − 2.16 | 4.05 × 10−5 | |
PFKFB3 | YBL | 4.28 × 10−3 | 3.66 | 7.00 × 10−3 | |
CHURC1 | MS/ YBL | 1.59 × 10−2/ 1.63 × 10− 2 | − 2.01 | 1.36 × 10− 2 | |
TRMT112 | YBL | 1.94 × 10−2 | − 2.56 | 1.01 × 10−6 | |
PLEKHA1 | MS | 2.29 × 10−2 | − 2.62 | 7.66 × 10−5 | |
AFF3 | YBL | 2.62 × 10−2 | − 2.35 | 2.08 × 10−4 | |
S100P | YBL | 3.31 × 10−2 | 5.49 | 2.29 × 10−2 | |
PSMC5 | YBL | 4.68 × 10−2 | − 2.22 | 4.21 × 10−7 | |
C1QTNF4 | MS | 4.96 × 10−2 | 3.32 | 2.38 × 10−5 | |
SDH | SUPV3L1 | YBL | 3.59 × 10−3 | 3.22 | – |
ZNF195 | YBL | 6.67 × 10− 3 | 2.25 | – | |
HBG2 | YBL | 2.36 × 10−2 | 3.91 | – | |
VAMP4 | YBL | 4.77 × 10−2 | 2.23 | – |