Biomarkers
|
Adjusted Means (SE)a
|
Placebo (n = 8)
|
Riociguat (n = 9)
|
p-value
|
cGMP (nM)
|
41.22 (50.2)
|
198.5 (47.03)
|
0.046
|
CXCL4 (ng/ml)
|
-7.3 (105.9)
|
-190.7 (99.8)
|
0.23
|
sE-Selectin (ng/ml)
|
-2.5 (2.0)
|
-4.7 (1.9)
|
0.45
|
VEGF (pg/ml)
|
-34.7 (10.1)
|
-29.8 (9.5)
|
0.73
|
sFLT1 (pg/ml)
|
-218.0 (211.8)
|
-220.5 (183.2)
|
0.99
|
tPA (ng/ml)
|
-0.5 (0.5)
|
-1.2 (0.5)
|
0.32
|
bFGF (pg/ml)
|
-0.03 (0.29)
|
0.20 (0.28)
|
0.58
|
sICAM1 (ng/ml)
|
-39.2 (50.2)
|
70.5 (47.3)
|
0.14
|
VCAM1 (ng/ml)
|
-3.4 (11.0)
|
10.3 (10.4)
|
0.39
|
PINP (pg/ml)
|
-6.6 (11.0)
|
7.1 (10.3)
|
0.38
|
MMP12 (ng/ml)
|
0.12 (0.14)
|
-0.09 (0.13)
|
0.31
|
Endostatin (ng/ml)
|
-96.8 (132.2)
|
-299.0 (124.5)
|
0.29
|
- 1biomarker values analyzed on natural scale using ANCOVA, adjusting for baseline biomarker value