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Table 2 Comparison of the incidence rates of developing various immune-mediated inflammatory diseases between AS patients and non-AS individuals

From: Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study

Autoimmune disease Total Event (%) Total person-years Incidence rate (/105 years) IRR (95% CI)
Acute anterior uveitis
 Non-AS 307,265 420 (0.14) 1,233,168 34.1 Reference
 AS 28,335 643 (2.13) 103,487 583.6 17.14 (15.13–19.41)
Psoriasis
 Non-AS 307,048 508 (0.17) 1,231,732 41.2 Reference
 AS 30,240 176 (0.58) 111,703 157.6 3.82 (3.22–4.53)
Inflammatory bowel disease
 Non-AS 299,243 12 (0.004) 1,205,603 1.0 Reference
 AS 29,462 9 (0.03) 109,791 8.2 8.24 (3.47–19.55)
Crohn’s disease
 Non-AS 299,776 4 (0.001) 1,207,612 0.3 Reference
 AS 29,560 3 (0.01) 110,132 2.7 8.22 (1.84–36.75)
Ulcerative colitis
 Non-AS 308,500 8 (0.003) 1,238,652 0.6 Reference
 AS 30,793 7 (0.02) 114,074 6.1 9.50 (3.45–26.20)
Systemic lupus erythematosus
 Non-AS 308,500 40 (0.01) 1,238,580 3.2 Reference
 AS 30,517 29 (0.10) 113,090 25.6 88.20 (11.03–705.18)
Sjögren’s syndrome
 Non-AS 306,049 80 (0.03) 1,230,358 6.5 Reference
 AS 29,772 91 (0.31) 110,650 82.2 12.65 (9.37–17.08)
Rheumatoid arthritis
 Non-AS 305,326 112 (0.04) 1,226,848 9.1 Reference
 AS 27,531 190 (0.69) 102,233 185.9 20.36 (16.12–25.71)
Systemic sclerosis
 Non-AS 309,048 9 (0.003) 1,240,674 0.7 Reference
 AS 30,872 8 (0.03) 114,346 7.0 9.64 (3.72–25.00)
Dermatomyositis
 Non-AS 308,846 8 (0.003) 1,239,911 0.6 Reference
 AS 30,843 4 (0.01) 114,233 3.5 5.43 (1.63–18.02)
Polymyositis
 Non-AS 308,832 2 (0.001) 1,239,818 0.2 Reference
 AS 30,827 2 (0.01) 114,166 1.8 10.86 (1.53–77.10)
Thromboangiitis obliterans
 Non-AS 309,093 2 (0.001) 1,240,854 0.2 Reference
 AS 30,907 3 (0.01) 114,474 2.6 16.26 (2.72–97.31)
Behcet’s disease
 Non-AS 309,039 4 (0.001) 1,240,654 0.3 Reference
 AS 30,820 21 (0.07) 114,144 18.4 57.06 (19.59–166.24)
Pemphigus
 Non-AS 309,061 4 (0.001) 1,240,728 0.3 Reference
 AS 30,906 2 (0.01) 114,477 1.7 5.42 (0.99–29.59)
Sarcoidosis
 Non-AS 309,088 21 (0.01) 1,240,775 1.7 Reference
 AS 30,897 16 (0.05) 114,402 14.0 8.26 (4.31–15.84)
Vitiligo
 Non-AS 308,750 98 (0.03) 1,239,523 7.9 Reference
 AS 30,838 21 (0.07) 114,251 18.4 2.32 (1.45–3.72)
  1. Abbreviations: AS ankylosing spondylitis, IRR incidence rate ratio, CI confidence interval