Table 2 Association summary statistics of three significant CNV segments at 2q14.3 associated with CDAI-based response to TNF-α blocker therapy in 357 patients with RA
Non-responder; n (%) | Responder; n (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Chr | Region | Regression coefficient of deletion (95% CI) | CN = 1 | CN = 2 | CN = 3 | CN = 1 | CN = 2 | CN = 3 | P |
2 | 129,459,141–129,461,606 | 8.16 (4.52 to 11.79) | 7 (22.9%) | 25 (78.1%) | 0 (0.0%) | 13 (4.0%) | 311 (95.7%) | 1 (0.3%) | 1.37 × 10−5 |
2 | 129,458,197–129,459,141 | 7.19 (3.68 to 10.70) | 7 (22.9%) | 25 (78.1%) | 0 (0.0%) | 15 (4.2%) | 309 (95.1%) | 1 (0.3%) | 6.97 × 10−5 |
2 | 129,457,798–129,458,197 | 7.28 (3.69 to 10.86) | 7 (22.9%) | 25 (78.1%) | 0 (0.0%) | 14 (3.8%) | 310 (95.4%) | 1 (0.3%) | 7.90 × 10−5 |