Fig. 4

CCR6+ ILC/total ILC ratio in SF of RA patients is positively correlated with SJC and TJC. a Gating strategy for CCR6+ ILCs. ILCs were defined as CD45+, lineage−, and CD127+ cells. b Proportion of ILC1s, ILC2s, NKp44− ILC3s, NKp44+ ILC3s, and CCR6+ ILCs in SF of patients with RA. The proportion of CCR6+ ILCs relative to total ILCs varied widely. Results are expressed as the median and interquartile range and analyzed based on the Wilcoxon rank-sum test. (*p < 0.05, **p < 0.01, ***p < 0.001). c Correlation of the proportion of CCR6+ ILCs in SF and either tender joint count or swollen joint count. Data are presented as scatter plots with a linear fit and analyzed using Spearman’s rank correlation coefficient. d Heat map showing correlation coefficients between ILC subsets and various clinical parameters as analyzed by calculating Spearman’s rank correlation coefficient. The value of the axis shows a correlation coefficient. (*p < 0.05, **p < 0.01, ***p < 0.001)