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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Interferon-α exacerbates neuropsychiatric phenotypes in lupus-prone mice

Fig. 5

Effect of IFN-α on cognitive function in NZB/NZW F1 mice, as assessed by the step-down passive avoidance test and the novelty Y-maze task. Latency (a) and percentage to reach criterion (b) of IFN-α-treated mice and control mice in the step-down passive avoidance test and in the novelty Y-maze task. c Illustrative example of the travel path of a control mouse and an IFN-α-treated mouse in the Y-maze. d Time spent in the arms per entry. Number of animals per group = 10. *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.001 vs. Adv-ctrl-treated group, two-way ANOVA with Sidak’s test

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