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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis

Fig. 1

Surgical induction of OA in +/+ mice causes increased ER stress in articular chondrocytes. a Safranin O staining of sections from non-operated and DMM-operated knee joints from +/+ mice at 2, 4 and 8 weeks post-DMM. The insert shows an expanded view of the highlighted black box. +/+ mice developed progressive OA as evidenced by the loss of safranin O staining and increasing degree of cartilage degradation. Col2a1 and BiP in situ hydrisation (ISH) was performed on sections from non-operated control joints and DMM-operated joints at 2, 4 and 8 weeks post-DMM. The presence of transcript is indicated by the blue staining (arrows). +/+ DMM-operated knee joints exhibited an increase in Col2a1 and BiP expression compared to non-operated joints. b Histological scores of OA pathology using a semi-quantitative scoring system. +/+ mice exhibited significant increase in the severity of OA with time. Results are the average score ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. LFC = lateral femoral condyle; LTP = lateral tibial plateau; MFC = medial femoral condyle; MTP = medial tibial plateau; Non-op = non-operated. Scale bar = 100 μm

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