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Table 1 Fifty most dysregulated genes in articular cartilage of +/+ DMM compared to SHAM and the equivalent expression in the ColIITgcog DMM group

From: Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis

WT DMM v SHAM

 

ColIITg cog DMM v SHAM

p adj

Fold change

Gene name

Fold change

p adj

3.91E−63

11.51

Inhba*

32.40

2.13E−102

1.0308E−29

−8.60

Adamts18*

− 3.93

5.81E−08

2.85E−27

6.85

Bmp7*

6.93

3.89E−24

1.1299E−24

4.33

Gpx3

7.45

8.48E−36

9.0276E−24

4.23

Pappa

6.26

4.43E−13

5.1868E−21

3.30

Fn1*

5.35

6.87E−22

7.9751E−21

3.74

Ank*

4.51

1.70E−27

2.4681E−20

3.52

Ctsh*

3.05

2.73E−06

7.7114E−19

5.44

Penk*

8.26

4.71E−27

4.0057E−18

5.00

Prkg2*

5.09

6.04E−13

5.266E−18

−3.87

Gas1

− 1.01

NS

7.7024E−18

−2.86

Fibin

− 1.82

1.03E−06

3.6914E−17

−3.07

Scara3*

− 1.30

NS

8.5273E−17

5.33

Hbegf*

8.52

1.14E−17

4.1624E−15

2.47

Pmepa1

3.65

9.44E−31

4.6948E−15

2.43

Tm4sf1*

4.13

3.90E−46

4.7632E−15

2.38

Galnt1*

2.90

3.33E−21

8.6454E−15

2.91

Hspa4l*

4.20

2.41E−38

1.9886E−14

−2.39

Comp

− 1.42

0.04857489

5.7638E−14

2.19

Col6a3*

2.56

2.20E−10

9.9399E−14

3.50

Bmp2*

4.52

2.87E−12

9.9399E−14

2.88

Mgp

10.33

1.91E−176

6.1568E−13

−6.41

Adamtsl2*

−3.04

0.020992517

1.585E−12

3.93

Npr3*

2.82

0.00016205

2.4475E−12

2.99

Fgf1*

1.32

NS

5.4612E−12

3.32

Bhlhe40*

4.46

3.58E−18

1.0334E−11

−3.05

Chad*

− 1.68

0.000147026

2.5909E−11

3.29

Serpine1

3.47

3.56E−07

3.7608E−11

3.47

Serpina3n*

22.32

NA

8.3862E−11

−3.15

Abi3bp

− 2.12

8.81E−08

8.3862E−11

−3.79

Ppp1r3c

− 2.52

0.000331801

2.0827E−10

5.13

Gcnt4

5.37

1.97E−08

2.3682E−10

−6.84

Omd*

− 2.47

0.0655615

2.5468E−10

2.36

Uaca*

2.84

3.35E−31

5.2059E−10

3.88

Fhl2*

3.45

1.43E−08

6.9381E−10

5.09

Ltbp2*

7.81

NA

6.9381E−10

3.34

Cyr61*

3.39

1.54E−07

3.0948E−09

7.13

Ptgs2*

15.18

NA

4.7855E−09

2.42

Cplx2

1.42

0.03383883

5.5902E−09

−2.03

Cytl1

− 1.04

NS

6.2564E−09

1.76

Atp1a1*

2.44

4.53E−22

7.6081E−09

2.50

Tsc22d1*

3.35

1.32E−14

1.598E−08

−2.44

Gm16070

− 1.66

0.017891341

2.3008E−08

−1.92

Lox

1.29

0.019344488

3.2292E−08

1.85

Col6a2*

2.73

2.23E−08

4.9035E−08

1.91

Lmo4

1.36

0.037644471

6.6389E−08

4.58

Hmga2*

6.95

3.62E−11

8.9945E−08

2.35

Emp1*

3.26

5.00E−09

1.312E−07

6.00

Gdf6

ND

NA

1.52E−07

−2.07

Nampt

− 1.15

NS

  1. Data compiled from Additional file 2: Table S2 &S3. Italics—genes significantly dysregulated in both WT DMM and ColIITgcog DMM compared to SHAM. *Gene also significantly dysregulated in similar direction in 2-week post-DMM wild-type cartilage samples assessed by microarray [29]. ND not detected, NA not available due to only one value in data set, NS not significant (false discovery rate/adjusted P value > 0.1)