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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: JAG2/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix

Fig. 4

JAG2/Notch2 signaling inhibited TNF-α-induced apoptosis in NP cells. a, b TNF-α treatment increased the apoptotic rate of NP cells, which was reversed by recombinant JAG2 treatment; Notch2/Hey2/Hes1 siRNA significantly enhanced the apoptotic rate induced by TNF-α treatment. c, d TUNEL assay showed that TNF-α increased the apoptotic rate of NP cells, which was reversed by JAG2 treatment; Notch2/Hey2/Hes1 siRNA enhanced the apoptotic rate induced by TNF-α. P values were computed vs. non-stimulated controls*, TNF-α-stimulated controls#, or JAG2-stimulated controls&; *,#,&P < 0.05

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