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Fig. 8 | Arthritis Research & Therapy

Fig. 8

From: JAG2/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix

Fig. 8

Summary of the findings and proposed mechanisms. Our data indicated that JAG2/Notch2 inhibited IVDD by modulating cell proliferation, apoptosis, and extracellular matrix. The JAG2/Notch2 axis induced NP cell proliferation via PI3K/Akt and Wnt/β-catenin signaling and inhibited TNF-α-induced apoptosis by suppressing the formation of the RIP1-FADD-caspase-8 complex. In conclusion, JAG2/Notch2 inhibited IVDD by modulating cell proliferation, apoptosis, and extracellular matrix

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