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Table 1 Patient characteristics according to systemic rheumatic disease

From: Comparing the burdens of opportunistic infections among patients with systemic rheumatic diseases: a nationally representative cohort study

Variable SLE (N = 15,961) PM/DM (N = 2270) SSc (N = 2071) RA (N = 38,355) pSS (N = 18,309)
Sex, n (%)
 Male 2027 (12.7) 760 (33.5) 544 (26.3) 9013 (23.5) 2032 (11.1)
 Female 13,934 (87.3) 1510 (66.5) 1527 (73.7) 29,342 (76.5) 16,277 (88.9)
Age in years, mean ± SD 37.2 ± 17.0 47.8 ± 17.7 51.8 ± 15.3 53.3 ± 15.4 54.7 ± 14.3
Age group, n (%)
 0–16 years 1342 (8.4) 148 (6.5) 32 (1.6) 712 (1.8) 42 (0.2)
 16–45 years 9853 (61.7) 767 (33.8) 610 (29.4) 9688 (25.3) 4363 (23.8)
 45–65 years 3512 (22.1) 975 (43.0) 1000 (48.3) 19,105 (49.8) 9456 (51.6)
 > 65 years 1254 (7.8) 380 (16.7) 429 (20.7) 8850 (23.1) 4448 (24.4)
Income in NTD, n (%)
 Low (< 19,200) 8092 (50.7) 1270 (56.0) 1129 (54.5) 20,647 (53.8) 9521 (52.0)
 Intermediate (19,201–40,000) 6071 (38.1) 747 (32.9) 721 (34.8) 14,024 (36.5) 6526 (35.6)
 High (> 40,000) 1798 (11.2) 253 (11.1) 221 (10.7) 3684 (9.7) 2262 (12.4)
Comorbidities, n (%)
 Diabetes mellitus 807 (5.1) 255 (11.3) 226 (11.0) 4528 (11.8) 2116 (11.5)
 Hypertension 2574 (16.1) 536 (23.6) 556 (26.8) 10,485 (27.3) 5277 (28.8)
 Chronic kidney disease 1390 (8.7) 99 (4.4) 147 (7.1) 1839 (4.8) 1064 (5.8)
 COPD 862 (5.4) 240 (10.6) 273 (13.2) 3930 (10.3) 2218 (12.1)
 Ischaemic heart disease 971 (6.1) 264 (11.6) 282 (13.6) 4643 (12.1) 2892 (15.9)
 Dyslipidaemia 1202 (7.5) 381 (16.8) 315 (15.3) 5743 (14.9) 3634 (19.8)
 CHF 541 (3.4) 105 (4.6) 147 (7.1) 1303 (3.4) 584 (3.2)
 Liver cirrhosis 270 (1.69) 37 (1.6) 58 (2.8) 444 (1.1) 401 (2.2)
 Cerebrovascular disease 7.3 (4.4) 101 (4.5) 126 (6.1) 2235 (5.8) 1658 (9.1)
 Cancer 739 (4.6) 279 (12.3) 128 (6.2) 2116 (5.5) 1567 (8.5)
 Peripheral artery disease 942 (5.9) 140 (6.2) 624 (30.1) 1314 (3.4) 1145 (6.25)
 HBV infection 317 (2.0) 113 (4.9) 46 (2.2) 1118 (2.9) 727 (3.9)
 HCV infection 249 (1.6) 54 (2.4) 39 (1.9) 877 (2.3) 705 (3.8)
 Depression 735 (4.6) 109 (4.8) 110 (5.3) 2265 (5.9) 2262 (12.3)
 Dementia 92 (0.6) 13 (0.6) 12 (0.6) 322 (0.8) 279 (1.5)
Medications, n (%)
 Corticosteroid 13,846 (86.7) 2146 (94.5) 1442 (69.6) 29,284 (76.3) 8912 (48.7)
 Cyclophosphamide 1320 (8.3) 208 (9.2) 186 (9.0) 192 (0.5) 229 (1.25)
 Methotrexate 626 (3.9) 668 (29.4) 155 (7.5) 21,310 (55.6) 829 (4.5)
 Azathioprine 3965 (24.8) 708 (31.2) 166 (8.0) 621 (1.6) 1104 (6.0)
 Cyclosporine 270 (1.7) 99 (4.4) 37 (1.8) 1105 (2.9) 104 (0.57)
 Leflunomide 35 (0.21) 15 (0.7) 11 (0.5) 1914 (5.0) 108 (0.59)
Length of follow-up (years), mean ± SD 5.6 ± 4.2 4.5 ± 4.1 5.3 ± 4.0 5.9 ± 3.9 4.5 ± 3.5
  1. SLE systemic lupus erythematosus, PM/DM polymyositis/dermatomyositis, RA rheumatoid arthritis, pSS primary Sjögren’s syndrome, SSc systemic sclerosis, SD standard deviation, NTD New Taiwan dollars, COPD chronic obstructive pulmonary disease, CHF congestive heart failure, HBV hepatitis B virus, HCV hepatitis C virus