| |
SLE (N = 15,961, PY = 89,256)
|
PM/DM (N = 2270, PY = 10,252)
|
SSc (N = 2071, PY = 10,868)
|
RA (N = 38,355, PY = 22,7549)
|
pSS (N = 18,309, PY = 81,995)
|
|---|
|
Events
|
IR (95% CI)
|
Events
|
IR (95% CI)
|
Events
|
IR (95% CI)
|
Events
|
IR (95% CI)
|
Events
|
IR (95% CI)
|
|---|
|
Fungus
|
|
Aspergillus
|
16
|
0.18 (0.10–0.29)
|
6
|
0.59 (0.22–1.27)
|
1
|
0.09 (0.01–0.51)
|
22
|
0.10 (0.06–0.15)
|
5
|
0.06 (0.02–0.14)
|
|
Candidiasis
|
388
|
4.35 (3.93–4.80)
|
85
|
8.29 (6.62–10.25)
|
49
|
4.51 (3.34–5.96)
|
426
|
1.87 (1.70–2.06)
|
145
|
1.77 (1.49–2.08)
|
|
Cryptococcus
|
39
|
0.44 (0.31–0.60)
|
9
|
0.88 (0.40–1.67)
|
2
|
0.18 (0.02–0.67)
|
45
|
0.20 (0.14–0.27)
|
14
|
0.17 (0.09–0.29)
|
|
PJP
|
45
|
0.51 (0.37–0.67)
|
18
|
1.76 (1.04–2.78)
|
4
|
0.37 (0.10–0.94)
|
18
|
0.08 (0.05–0.13)
|
9
|
0.11 (0.05–0.21)
|
|
Subtotal
|
488
|
5.48 (4.99–5.98)
|
118
|
11.5 (9.53–13.8)
|
56
|
5.15 (3.89–6.69)
|
511
|
2.25 (2.06–2.45)
|
173
|
2.11 (1.81–2.45)
|
|
CMV
|
100
|
1.12 (0.91–1.37)
|
18
|
1.76 (1.04–2.78)
|
4
|
0.37 (0.10–0.94)
|
29
|
0.13 (0.09–0.18)
|
15
|
0.18 (0.10–0.30)
|
|
Salmonellosis
|
272
|
3.05 (2.70–3.43)
|
30
|
2.93 (1.97–4.18)
|
11
|
1.01 (0.51–1.81)
|
118
|
0.52 (0.43–0.62)
|
27
|
0.33 (0.22–0.48)
|
|
Herpes zoster
|
2580
|
28.9 (27.8–30.0)
|
377
|
36.8 (33.2–40.7)
|
216
|
19.9 (17.3–22.7)
|
4084
|
17.9 (17.4–18.5)
|
1502
|
18.3 (17.4–19.3)
|
|
TB
|
341
|
3.82 (3.43–4.25)
|
71
|
6.93 (5.41–8.74)
|
47
|
4.32 (3.18–5.75)
|
839
|
3.69 (3.44–3.95)
|
213
|
2.60 (2.26–2.97)
|
|
NTM
|
63
|
0.71 (0.54–0.90)
|
14
|
1.37 (0.75–2.29)
|
9
|
0.82 (0.38–1.57)
|
121
|
0.53 (0.44–0.64)
|
48
|
0.59 (0.43–0.78)
|
|
Non-herpes zoster infection
|
1264
|
14.2 (13.4–15.0)
|
251
|
24.5 (21.6–27.7)
|
127
|
11.7 (9.74–13.9)
|
1617
|
7.10 (6.76–7.40)
|
476
|
5.81 (5.30–6.35)
|
|
Total
|
3844
|
43.1 (41.7–44.5)
|
628
|
61.3 (56.6–66.2)
|
343
|
31.6 (28.3–35.1)
|
5701
|
25.0 (24.4–25.7)
|
1978
|
24.1 (23.1–25.2)
|
- Incidence rates (IRs) are reported as the number of cases per 1000 person-years
- SLE systemic lupus erythematosus, RA rheumatoid arthritis, pSS primary Sjögren’s syndrome, SSc systemic sclerosis, PM/DM polymyositis/dermatomyositis, PJP Pneumocystis jiroveci pneumonia, CMV cytomegalovirus, TB tuberculosis, NTM non-tuberculosis mycobacterium, PY person-years
