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Table 2 Incidence rates of opportunistic infections according to systemic rheumatic disease

From: Comparing the burdens of opportunistic infections among patients with systemic rheumatic diseases: a nationally representative cohort study

  SLE (N = 15,961, PY = 89,256) PM/DM (N = 2270, PY = 10,252) SSc (N = 2071, PY = 10,868) RA (N = 38,355, PY = 22,7549) pSS (N = 18,309, PY = 81,995)
Events IR (95% CI) Events IR (95% CI) Events IR (95% CI) Events IR (95% CI) Events IR (95% CI)
Fungus
 Aspergillus 16 0.18 (0.10–0.29) 6 0.59 (0.22–1.27) 1 0.09 (0.01–0.51) 22 0.10 (0.06–0.15) 5 0.06 (0.02–0.14)
 Candidiasis 388 4.35 (3.93–4.80) 85 8.29 (6.62–10.25) 49 4.51 (3.34–5.96) 426 1.87 (1.70–2.06) 145 1.77 (1.49–2.08)
 Cryptococcus 39 0.44 (0.31–0.60) 9 0.88 (0.40–1.67) 2 0.18 (0.02–0.67) 45 0.20 (0.14–0.27) 14 0.17 (0.09–0.29)
 PJP 45 0.51 (0.37–0.67) 18 1.76 (1.04–2.78) 4 0.37 (0.10–0.94) 18 0.08 (0.05–0.13) 9 0.11 (0.05–0.21)
 Subtotal 488 5.48 (4.99–5.98) 118 11.5 (9.53–13.8) 56 5.15 (3.89–6.69) 511 2.25 (2.06–2.45) 173 2.11 (1.81–2.45)
CMV 100 1.12 (0.91–1.37) 18 1.76 (1.04–2.78) 4 0.37 (0.10–0.94) 29 0.13 (0.09–0.18) 15 0.18 (0.10–0.30)
Salmonellosis 272 3.05 (2.70–3.43) 30 2.93 (1.97–4.18) 11 1.01 (0.51–1.81) 118 0.52 (0.43–0.62) 27 0.33 (0.22–0.48)
Herpes zoster 2580 28.9 (27.8–30.0) 377 36.8 (33.2–40.7) 216 19.9 (17.3–22.7) 4084 17.9 (17.4–18.5) 1502 18.3 (17.4–19.3)
TB 341 3.82 (3.43–4.25) 71 6.93 (5.41–8.74) 47 4.32 (3.18–5.75) 839 3.69 (3.44–3.95) 213 2.60 (2.26–2.97)
NTM 63 0.71 (0.54–0.90) 14 1.37 (0.75–2.29) 9 0.82 (0.38–1.57) 121 0.53 (0.44–0.64) 48 0.59 (0.43–0.78)
Non-herpes zoster infection 1264 14.2 (13.4–15.0) 251 24.5 (21.6–27.7) 127 11.7 (9.74–13.9) 1617 7.10 (6.76–7.40) 476 5.81 (5.30–6.35)
Total 3844 43.1 (41.7–44.5) 628 61.3 (56.6–66.2) 343 31.6 (28.3–35.1) 5701 25.0 (24.4–25.7) 1978 24.1 (23.1–25.2)
  1. Incidence rates (IRs) are reported as the number of cases per 1000 person-years
  2. SLE systemic lupus erythematosus, RA rheumatoid arthritis, pSS primary Sjögren’s syndrome, SSc systemic sclerosis, PM/DM polymyositis/dermatomyositis, PJP Pneumocystis jiroveci pneumonia, CMV cytomegalovirus, TB tuberculosis, NTM non-tuberculosis mycobacterium, PY person-years