Follow-up years | Person-year | Total opportunistic infections | Non-herpes zoster opportunistic infections | ||||
---|---|---|---|---|---|---|---|
Events | IR | IRR | Events | IR | IRR | ||
SLE | |||||||
 0–1 | 14,355 | 1212 | 84.4 | 2.76 (2.53–2.99) | 425 | 29.6 | 2.86 (2.48–3.31) |
 1–2 | 12,495 | 540 | 43.2 | 1.41 (1.27–1.57) | 168 | 13.5 | 1.30 (1.07–1.58) |
 2–3 | 11,050 | 418 | 37.8 | 1.24 (1.10–1.38) | 126 | 11.4 | 1.10 (0.89–1.36) |
 3–4 | 9729 | 359 | 36.9 | 1.20 (1.06–1.36) | 106 | 10.9 | 1.05 (0.84–1.31) |
 4–5 | 8483 | 300 | 35.3 | 1.15 (1.01–1.31) | 96 | 11.3 | 1.09 (0.86–1.38) |
 > 5 | 33,144 | 1015 | 30.6 | 1 (reference) | 343 | 10.4 | 1 (reference) |
 Total | 89,256 | 3844 | 43.1 | – | 1264 | 14.2 | – |
RA | |||||||
 0–1 | 36,271 | 1123 | 30.9 | 1.32 (1.23–1.43) | 331 | 9.13 | 1.44 (1.25–1.66) |
 1–2 | 32,300 | 825 | 25.5 | 1.09 (1.01–1.18) | 226 | 7.00 | 1.10 (0.94–1.29) |
 2–3 | 28,646 | 676 | 23.6 | 1.01 (0.92–1.10) | 201 | 7.02 | 1.11 (0.94–1.31) |
 3–4 | 25,375 | 596 | 23.5 | 1.01 (0.91–1.10) | 165 | 6.51 | 1.03 (0.86–1.22) |
 4–5 | 22,283 | 547 | 24.5 | 1.05 (0.95–1.15) | 170 | 7.63 | 1.20 (1.01–1.43) |
 > 5 | 82,674 | 1934 | 23.4 | 1 (reference) | 524 | 6.34 | 1 (reference) |
 Total | 227,549 | 5701 | 25.0 | – | 1617 | 7.10 | – |
pSS | |||||||
 0–1 | 16,658 | 528 | 31.7 | 1.54 (1.36–1.75) | 152 | 9.12 | 1.85 (1.44–2.37) |
 1–2 | 13,798 | 355 | 25.7 | 1.25 (1.08–1.43) | 71 | 5.15 | 1.04 (0.76–1.41) |
 2–3 | 11,438 | 242 | 21.1 | 1.03 (0.88–1.20) | 49 | 4.28 | 0.87 (0.61–1.22) |
 3–4 | 9386 | 196 | 20.8 | 1.01 (0.85–1.20) | 47 | 5.01 | 1.01 (0.71–1.43) |
 4–5 | 7657 | 182 | 23.7 | 1.15 (0.97–1.37) | 43 | 5.62 | 1.14 (0.78–1.62) |
 > 5 | 23,058 | 475 | 20.6 | 1 (reference) | 114 | 4.94 | 1 (reference) |
 Total | 81,995 | 1978 | 24.1 | – | 476 | 5.81 | – |
SSc | |||||||
 0–1 | 1875 | 80 | 42.6 | 1.61 (1.18–2.18) | 34 | 18.1 | 1.68 (1.04–2.72) |
 1–2 | 1600 | 57 | 35.6 | 1.34 (0.95–1.88) | 18 | 11.2 | 1.04 (0.56–1.86) |
 2–3 | 1380 | 46 | 33.3 | 1.26 (0.87–1.80) | 16 | 11.5 | 1.08 (0.56–1.96) |
 3–4 | 1183 | 40 | 33.8 | 1.27 (0.86–1.85) | 11 | 9.29 | 0.86 (0.40–1.71) |
 4–5 | 1024 | 19 | 18.5 | 0.70 (0.40–1.15) | 7 | 6.83 | 0.63 (0.24–1.43) |
 > 5 | 3806 | 101 | 26.5 | 1 (reference) | 41 | 10.7 | 1 (reference) |
 Total | 10,868 | 343 | 31.6 | – | 127 | 11.7 | – |
PM/DM | |||||||
 0–1 | 1882 | 277 | 147.2 | 5.47 (4.31–6.98) | 137 | 72.8 | 11.2 (7.14–18.2) |
 1–2 | 1510 | 100 | 66.2 | 2.46 (1.84–3.29) | 36 | 23.8 | 3.66 (2.11–6.46) |
 2–3 | 1277 | 78 | 61.1 | 2.27 (1.66–3.09) | 23 | 18.8 | 2.76 (1.48–5.15) |
 3–4 | 1098 | 42 | 38.2 | 1.42 (0.96–2.06) | 17 | 15.4 | 2.37 (1.19–4.64) |
 4–5 | 957 | 36 | 37.6 | 1.40 (0.92–2.07) | 15 | 15.6 | 2.40 (1.17–4.81) |
 > 5 | 3528 | 95 | 26.9 | 1 (reference) | 23 | 6.51 | 1 (reference) |
 Total | 10,252 | 628 | 61.3 | – | 127 | 24.5 | – |