Skip to main content

Table 4 Incidence rates and ratios for total opportunistic infections and non-herpes zoster infections according to systemic rheumatic disease and follow-up duration

From: Comparing the burdens of opportunistic infections among patients with systemic rheumatic diseases: a nationally representative cohort study

Follow-up years Person-year Total opportunistic infections Non-herpes zoster opportunistic infections
Events IR IRR Events IR IRR
SLE
 0–1 14,355 1212 84.4 2.76 (2.53–2.99) 425 29.6 2.86 (2.48–3.31)
 1–2 12,495 540 43.2 1.41 (1.27–1.57) 168 13.5 1.30 (1.07–1.58)
 2–3 11,050 418 37.8 1.24 (1.10–1.38) 126 11.4 1.10 (0.89–1.36)
 3–4 9729 359 36.9 1.20 (1.06–1.36) 106 10.9 1.05 (0.84–1.31)
 4–5 8483 300 35.3 1.15 (1.01–1.31) 96 11.3 1.09 (0.86–1.38)
 > 5 33,144 1015 30.6 1 (reference) 343 10.4 1 (reference)
 Total 89,256 3844 43.1 1264 14.2
RA
 0–1 36,271 1123 30.9 1.32 (1.23–1.43) 331 9.13 1.44 (1.25–1.66)
 1–2 32,300 825 25.5 1.09 (1.01–1.18) 226 7.00 1.10 (0.94–1.29)
 2–3 28,646 676 23.6 1.01 (0.92–1.10) 201 7.02 1.11 (0.94–1.31)
 3–4 25,375 596 23.5 1.01 (0.91–1.10) 165 6.51 1.03 (0.86–1.22)
 4–5 22,283 547 24.5 1.05 (0.95–1.15) 170 7.63 1.20 (1.01–1.43)
 > 5 82,674 1934 23.4 1 (reference) 524 6.34 1 (reference)
 Total 227,549 5701 25.0 1617 7.10
pSS
 0–1 16,658 528 31.7 1.54 (1.36–1.75) 152 9.12 1.85 (1.44–2.37)
 1–2 13,798 355 25.7 1.25 (1.08–1.43) 71 5.15 1.04 (0.76–1.41)
 2–3 11,438 242 21.1 1.03 (0.88–1.20) 49 4.28 0.87 (0.61–1.22)
 3–4 9386 196 20.8 1.01 (0.85–1.20) 47 5.01 1.01 (0.71–1.43)
 4–5 7657 182 23.7 1.15 (0.97–1.37) 43 5.62 1.14 (0.78–1.62)
 > 5 23,058 475 20.6 1 (reference) 114 4.94 1 (reference)
 Total 81,995 1978 24.1 476 5.81
SSc
 0–1 1875 80 42.6 1.61 (1.18–2.18) 34 18.1 1.68 (1.04–2.72)
 1–2 1600 57 35.6 1.34 (0.95–1.88) 18 11.2 1.04 (0.56–1.86)
 2–3 1380 46 33.3 1.26 (0.87–1.80) 16 11.5 1.08 (0.56–1.96)
 3–4 1183 40 33.8 1.27 (0.86–1.85) 11 9.29 0.86 (0.40–1.71)
 4–5 1024 19 18.5 0.70 (0.40–1.15) 7 6.83 0.63 (0.24–1.43)
 > 5 3806 101 26.5 1 (reference) 41 10.7 1 (reference)
 Total 10,868 343 31.6 127 11.7
PM/DM
 0–1 1882 277 147.2 5.47 (4.31–6.98) 137 72.8 11.2 (7.14–18.2)
 1–2 1510 100 66.2 2.46 (1.84–3.29) 36 23.8 3.66 (2.11–6.46)
 2–3 1277 78 61.1 2.27 (1.66–3.09) 23 18.8 2.76 (1.48–5.15)
 3–4 1098 42 38.2 1.42 (0.96–2.06) 17 15.4 2.37 (1.19–4.64)
 4–5 957 36 37.6 1.40 (0.92–2.07) 15 15.6 2.40 (1.17–4.81)
 > 5 3528 95 26.9 1 (reference) 23 6.51 1 (reference)
 Total 10,252 628 61.3 127 24.5
  1. IRs are reported as the number of cases per 1000 person-years
  2. IR incidence rate, IRR incidence rate ratio, SLE systemic lupus erythematosus, RA rheumatoid arthritis, pSS primary Sjögren’s syndrome, SSc systemic sclerosis, PM/DM polymyositis/dermatomyositis