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Table 4 Incidence rates and ratios for total opportunistic infections and non-herpes zoster infections according to systemic rheumatic disease and follow-up duration

From: Comparing the burdens of opportunistic infections among patients with systemic rheumatic diseases: a nationally representative cohort study

Follow-up years

Person-year

Total opportunistic infections

Non-herpes zoster opportunistic infections

Events

IR

IRR

Events

IR

IRR

SLE

 0–1

14,355

1212

84.4

2.76 (2.53–2.99)

425

29.6

2.86 (2.48–3.31)

 1–2

12,495

540

43.2

1.41 (1.27–1.57)

168

13.5

1.30 (1.07–1.58)

 2–3

11,050

418

37.8

1.24 (1.10–1.38)

126

11.4

1.10 (0.89–1.36)

 3–4

9729

359

36.9

1.20 (1.06–1.36)

106

10.9

1.05 (0.84–1.31)

 4–5

8483

300

35.3

1.15 (1.01–1.31)

96

11.3

1.09 (0.86–1.38)

 > 5

33,144

1015

30.6

1 (reference)

343

10.4

1 (reference)

 Total

89,256

3844

43.1

–

1264

14.2

–

RA

 0–1

36,271

1123

30.9

1.32 (1.23–1.43)

331

9.13

1.44 (1.25–1.66)

 1–2

32,300

825

25.5

1.09 (1.01–1.18)

226

7.00

1.10 (0.94–1.29)

 2–3

28,646

676

23.6

1.01 (0.92–1.10)

201

7.02

1.11 (0.94–1.31)

 3–4

25,375

596

23.5

1.01 (0.91–1.10)

165

6.51

1.03 (0.86–1.22)

 4–5

22,283

547

24.5

1.05 (0.95–1.15)

170

7.63

1.20 (1.01–1.43)

 > 5

82,674

1934

23.4

1 (reference)

524

6.34

1 (reference)

 Total

227,549

5701

25.0

–

1617

7.10

–

pSS

 0–1

16,658

528

31.7

1.54 (1.36–1.75)

152

9.12

1.85 (1.44–2.37)

 1–2

13,798

355

25.7

1.25 (1.08–1.43)

71

5.15

1.04 (0.76–1.41)

 2–3

11,438

242

21.1

1.03 (0.88–1.20)

49

4.28

0.87 (0.61–1.22)

 3–4

9386

196

20.8

1.01 (0.85–1.20)

47

5.01

1.01 (0.71–1.43)

 4–5

7657

182

23.7

1.15 (0.97–1.37)

43

5.62

1.14 (0.78–1.62)

 > 5

23,058

475

20.6

1 (reference)

114

4.94

1 (reference)

 Total

81,995

1978

24.1

–

476

5.81

–

SSc

 0–1

1875

80

42.6

1.61 (1.18–2.18)

34

18.1

1.68 (1.04–2.72)

 1–2

1600

57

35.6

1.34 (0.95–1.88)

18

11.2

1.04 (0.56–1.86)

 2–3

1380

46

33.3

1.26 (0.87–1.80)

16

11.5

1.08 (0.56–1.96)

 3–4

1183

40

33.8

1.27 (0.86–1.85)

11

9.29

0.86 (0.40–1.71)

 4–5

1024

19

18.5

0.70 (0.40–1.15)

7

6.83

0.63 (0.24–1.43)

 > 5

3806

101

26.5

1 (reference)

41

10.7

1 (reference)

 Total

10,868

343

31.6

–

127

11.7

–

PM/DM

 0–1

1882

277

147.2

5.47 (4.31–6.98)

137

72.8

11.2 (7.14–18.2)

 1–2

1510

100

66.2

2.46 (1.84–3.29)

36

23.8

3.66 (2.11–6.46)

 2–3

1277

78

61.1

2.27 (1.66–3.09)

23

18.8

2.76 (1.48–5.15)

 3–4

1098

42

38.2

1.42 (0.96–2.06)

17

15.4

2.37 (1.19–4.64)

 4–5

957

36

37.6

1.40 (0.92–2.07)

15

15.6

2.40 (1.17–4.81)

 > 5

3528

95

26.9

1 (reference)

23

6.51

1 (reference)

 Total

10,252

628

61.3

–

127

24.5

–

  1. IRs are reported as the number of cases per 1000 person-years
  2. IR incidence rate, IRR incidence rate ratio, SLE systemic lupus erythematosus, RA rheumatoid arthritis, pSS primary Sjögren’s syndrome, SSc systemic sclerosis, PM/DM polymyositis/dermatomyositis