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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Molecular profiling of rheumatoid arthritis patients reveals an association between innate and adaptive cell populations and response to anti-tumor necrosis factor

Fig. 2

Effect of anti-TNF treatment in EULAR-GR and EULAR-NR in C1 and C2. a At an individual gene level, the gene expression profile changes upon anti-TNF treatment are highly correlated between EULAR-GR and EULAR-NR, except for EULAR-NR from C2. b MO3-BL differences in gene expression averaged for GO categories most up/downregulated upon treatment (BH-FDR < 0.01) cluster by the direction of the treatment (orange—up, purple—downregulated at MO3), but not by clinical response (EULAR-GR—blue, EULAR-NR—red) in both cohorts. c Statistically significant positive correlation of MO3-BL differences in protein levels is observed between EULAR-GR and EULAR-NR in each cohort. d MO3-BL differences in plasma protein levels averaged for GO categories most up/downregulated upon treatment (BH-FDR = 0.2) cluster predominantly by the direction of the treatment (orange—up, purple—downregulated at MO3), but not by clinical response (EULAR-GR—blue, EULAR-NR—red) in both cohorts

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