Fig. 5

a Spearman correlations between CBC metrics (counts of neutrophils, lymphocytes, and their ratios) and average gene expression levels for gene sets predominantly expressed in major immune cell types. b Forest plot representation of the effects of baseline patient attributes on the probability of good or moderate response at 3 months follow-up. Odds ratios (ORs) for cell count log-ratios are estimated by three models using each of these log-ratios respectively in addition to the rest of the covariates shown below the blue dashed line. Representative ORs for the rest of the attributes are from the model including neutrophil-to-lymphocyte log-ratio as a covariate. OR for N-L, N-W, and L-W log-ratios are per 1 unit increase in natural logarithm of the corresponding ratio. OR for mHAQ is for 1 unit increase in mHAQ. OR for no. of prior biologics is for each additional prior biologic used. OR for age and duration of RA is for a 10-year increase in age and duration of RA, respectively, from the N-L ratio model. See main text for further details