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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Potential therapeutic effects of cyanidin-3-O-glucoside on rheumatoid arthritis by relieving inhibition of CD38+ NK cells on Treg cell differentiation

Fig. 5

Sirtuin6 (Sirt6) expression and its effect on CD38+ NK cells following C3G treatment. a Sirt6 expression level in CD38+ NK cells following C3G treatment using real-time PCR and Western blotting. b NKG2D mRNA level in CD38+ NK cells following C3G treatment using real-time PCR. c Sirt6 expression level in CD38+ NK cells following Sirt6 siRNA (siSirt 6) transfection with Allstars siRNA as a control using real-time PCR and Western blotting. d NKG2D mRNA level in CD38+ NK cells following Sirt6 siRNA transfection using real-time PCR. e IFN-γ and TNF-α concentration in the culture medium of CD38+ NK cells following treatment with Sirt6 siRNA and C3G. f Treg and IL-10+ Treg cell proportions in CD38+ NK-depleted MNCs. The MNCs were cocultured with CD38+ NK cells treated with Sirt6 siRNA and C3G. * indicates p < 0.05, **p < 0.01, and ***p < 0.001

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