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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture

Fig. 6

a Venn diagram showing distribution of 953 distinct proteins identified via mass spectrometry in day 2 conditioned media from IL-1-treated cartilage monoculture, synovium monoculture, and cartilage + synovium co-culture conditions. b Principal component analysis chart showing variances between samples based on proteins identified and their abundances. c Ratio of representative protein abundances identified in cartilage + synovium co-culture to either cartilage (C+S/C), synovium monoculture (C+S/S), or the sum of cartilage monoculture and synovium monoculture (C+S/Sum(C,S)) highlighting biological crosstalk. Data is presented as mean ± 95% confidence interval. * indicates significance between co-culture and denominator of ratio (p < 0.05). Statistical markers are color coordinated with all bars

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Arthritis Research & Therapy

ISSN: 1478-6362

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