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Table 2 Response*(%) at 3 and 6 months, stratified by certolizumab pegol level at 3 months

From: Associations between certolizumab pegol serum levels, anti-drug antibodies and treatment response in patients with inflammatory joint diseases: data from the NOR-DMARD study

 

Overall

CZP < 20 mg/L

CZP 20–39.9 mg/L

CZP ≥ 40 mg/L

OR** (95% CI)

P**

 

Responders* after 3 months

All patients (n = 245)

53%

35%

65%

49%

2.3 (1.2–4.5)

< 0.05

axSpA (n = 110)

40%

18%

53%

37%

3.4 (1.0–11.1)

< 0.05

RA (n = 81)

61%

44%

74%

55%

1.5 (0.5–5.1)

0.48

PsA (n = 54)

69%

47%

77%

77%

4.3 (1.0–17.9)

< 0.05

 

Responders* after 6 months

All patients (n = 245)

52%

38%

63%

48%

1.9 (1.0–3.5)

0.05

axSpA (n = 110)

40%

18%

55%

34%

3.3 (1.0–10.8)

< 0.05

RA (n = 81)

57%

50%

62%

55%

1.1 (0.3–3.4)

0.92

PsA (n = 54)

70%

53%

77%

70%

3.3 (0.8–13.3)

0.09

  1. CZP certolizumab pegol, OR odds ratio, CI confidence interval
  2. *Response in axial spondyloarthritis (axSpA) was defined by clinically important improvement the Ankylosing Spondylitis Disease Activity Score, in rheumatoid arthritis (RA) as European League Against Rheumatism good/moderate response, and in psoriatic arthritis (PsA) as improvement of ≥ 0.6 in 28-joint Disease Activity Score
  3. **Multivariate logistic regression comparing response in patients with CZP < 20 vs ≥ 20 mg/L, adjusting for age, sex and prior biologic disease-modifying antirheumatic drug use (yes/no)