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Table 2 Main suspected drug classes and drugs associated with febuxostat/allopurinol in reported cases of ARF

From: Acute kidney injury associated with febuxostat and allopurinol: a post-marketing study

  Number Percent
Febuxostat
 Anti-anemics/antihemorrhagics 64 11.4
  Darbepoetin alfa 43 7.7
 Diuretics 58 10.3
  Furosemide 25 4.4
  Hydrochlorothiazide 8 1.4
 Lipid-lowering agents 39 6.9
  Rosuvastatin 9 1.6
  Simvastatin 7 1.2
 Immunosuppressive therapies 37 6.6
  Tocilizumab 15 2.7
 Calcium channel blockers 33 5.9
  Amlodipine 16 2.8
  Nifedipine 7 1.2
 Antigout drugs 31 5.5
  Colchicine 15 2.7
  Allopurinol 14 2.5
 NSAIDs 17 3.0
  Diclofenac 5 0.9
  Ketoprofen 3 0.5
Allopurinol
 Diuretics 247 11.3
  Furosemide 107 4.9
  Hydrochlorothiazide 52 2.4
  Spironolactone 37 1.7
 Antibiotics 234 10.7
  Amoxicillin 27 1.2
  Sulfamethoxazole/trimethoprim 20 0.9
 Immunosuppressive therapies 163 7.5
  Tocilizumab 15 0.7
  Cyclosporine 11 0.5
  Lenalidomide 11 0.5
 ACEIs 112 5.1
  Perindopril 31 1.4
  Ramipril 26 1.2
 Antigout drugs 101 4.6
  Colchicine 75 3.4
  Febuxostat 14 0.6
 Sartans 100 4.6
  Valsartan 28 1.3
  Irbesartan 19 0.9
 NSAIDs 87 4.0
  Ibuprofen 21 1.0
  Diclofenac 15 0.7