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Table 2 Main suspected drug classes and drugs associated with febuxostat/allopurinol in reported cases of ARF

From: Acute kidney injury associated with febuxostat and allopurinol: a post-marketing study

 

Number

Percent

Febuxostat

 Anti-anemics/antihemorrhagics

64

11.4

  Darbepoetin alfa

43

7.7

 Diuretics

58

10.3

  Furosemide

25

4.4

  Hydrochlorothiazide

8

1.4

 Lipid-lowering agents

39

6.9

  Rosuvastatin

9

1.6

  Simvastatin

7

1.2

 Immunosuppressive therapies

37

6.6

  Tocilizumab

15

2.7

 Calcium channel blockers

33

5.9

  Amlodipine

16

2.8

  Nifedipine

7

1.2

 Antigout drugs

31

5.5

  Colchicine

15

2.7

  Allopurinol

14

2.5

 NSAIDs

17

3.0

  Diclofenac

5

0.9

  Ketoprofen

3

0.5

Allopurinol

 Diuretics

247

11.3

  Furosemide

107

4.9

  Hydrochlorothiazide

52

2.4

  Spironolactone

37

1.7

 Antibiotics

234

10.7

  Amoxicillin

27

1.2

  Sulfamethoxazole/trimethoprim

20

0.9

 Immunosuppressive therapies

163

7.5

  Tocilizumab

15

0.7

  Cyclosporine

11

0.5

  Lenalidomide

11

0.5

 ACEIs

112

5.1

  Perindopril

31

1.4

  Ramipril

26

1.2

 Antigout drugs

101

4.6

  Colchicine

75

3.4

  Febuxostat

14

0.6

 Sartans

100

4.6

  Valsartan

28

1.3

  Irbesartan

19

0.9

 NSAIDs

87

4.0

  Ibuprofen

21

1.0

  Diclofenac

15

0.7