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Table 2 Main suspected drug classes and drugs associated with febuxostat/allopurinol in reported cases of ARF

From: Acute kidney injury associated with febuxostat and allopurinol: a post-marketing study

 NumberPercent
Febuxostat
 Anti-anemics/antihemorrhagics6411.4
  Darbepoetin alfa437.7
 Diuretics5810.3
  Furosemide254.4
  Hydrochlorothiazide81.4
 Lipid-lowering agents396.9
  Rosuvastatin91.6
  Simvastatin71.2
 Immunosuppressive therapies376.6
  Tocilizumab152.7
 Calcium channel blockers335.9
  Amlodipine162.8
  Nifedipine71.2
 Antigout drugs315.5
  Colchicine152.7
  Allopurinol142.5
 NSAIDs173.0
  Diclofenac50.9
  Ketoprofen30.5
Allopurinol
 Diuretics24711.3
  Furosemide1074.9
  Hydrochlorothiazide522.4
  Spironolactone371.7
 Antibiotics23410.7
  Amoxicillin271.2
  Sulfamethoxazole/trimethoprim200.9
 Immunosuppressive therapies1637.5
  Tocilizumab150.7
  Cyclosporine110.5
  Lenalidomide110.5
 ACEIs1125.1
  Perindopril311.4
  Ramipril261.2
 Antigout drugs1014.6
  Colchicine753.4
  Febuxostat140.6
 Sartans1004.6
  Valsartan281.3
  Irbesartan190.9
 NSAIDs874.0
  Ibuprofen211.0
  Diclofenac150.7