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Table 1 Study participant characteristics

From: Fatigue severity in anti-nuclear antibody-positive individuals does not correlate with pro-inflammatory cytokine levels or predict imminent progression to symptomatic disease

  HC (n = 29) ANS (n = 46) UCTD (n = 29) SARD (n = 42) SjD (n = 11) SLE (n = 11) SSc (n = 18) MCTD/DM (n = 2)
Age, mean ± SD 29.3 ± 9.8 47.0 ± 14.0 48.3 ± 16.5 47.4 ± 14.9 47.7 ± 14.4 35.7 ± 12.3 54.7 ± 13.3 44 ± 1.4
Female sex, n (%) 25 (86.2) 44 (95.7) 27 (93.1) 40 (95.2) 10 (90.9) 11 (100) 16 (88.9) 2 (100)
Ethnicity, n (%)
 Caucasian 12 (41.4) 26 (56.5) 20 (69.0) 26 (61.9) 7 (63.6) 6 (54.5) 12 (66.7) 1 (50)
 Asian 0 (0) 3 (6.5) 5 (17.2) 2 (4.8) 1 (9.1) 0 (0) 1 (5.6) 0 (0)
 South Asian 5 (17.2) 5 (10.9) 2 (6.9) 5 (11.9) 2 (18.2) 1 (9.1) 2 (11.1) 0 (0)
 Hispanic 7 (24.1) 2 (4.3) 1 (3.4) 4 (9.5) 0 (0) 1 (9.1) 3 (16.7) 0 (0)
 African Canadian 1 (3.4) 7 (15.2) 0 (0) 1 (2.4) 0 (0) 1 (9.1) 0 (0) 0 (0)
 Filipino 1 (3.4) 1 (2.2) 0 (0) 2 (4.8) 0 (0) 1 (9.1) 0 (0) 1 (50)
 Mixed 3 (10.3) 2 (4.3) 1 (3.4) 2 (4.8) 1 (9.1) 1 (9.1) 0 (0) 0 (0)
Fibromyalgia, n (%) 0 (0) 17 (37.0) 13 (44.8) 12 (28.6) 2 (18.2) 3 (27.3) 6 (33.3) 1 (50.0)
Anemia, n (%) 0 (0) 4 (8.7) 0 (0) 2 (4.8) 0 (0) 1 (9.1) 1 (5.6) 0 (0)
Hypothyroidism, n (%) 0 (0) 4 (8.7) 0 (0) 2 (4.8) 1 (9.1) 0 (0) 1 (5.6) 0 (0)
Depression, n (%) 0 (0) 3 (6.5) 2 (6.9) 2 (4.8) 1 (9.1) 0 (0) 1 (5.6) 0 (0)
On anti-malarials, n (%) 0 (0) 4 (8.7) 6 (20.7) 4 (9.5) 1 (9.1) 2 (18.2) 1 (5.6) 0 (0)
Specific antibodies, n (%)
 dsDNA 0 (0) 4 (8.7) 2 (6.9) 7 (16.7) 2 (18.2) 3 (27.3) 2 (11.1) 0 (0)
 Ro 0 (0) 11 (23.9) 9 (31.0) 19 (45.2) 11 (100) 5 (45.5) 3 (16.7) 0 (0)
 La 0 (0) 4 (8.7) 2 (6.9) 8 (19.0) 7 (63.6) 1 (9.1) 0 (0) 0 (0)
 Sm 0 (0) 2 (4.3) 1 (3.4) 4 (9.5) 0 (0) 3 (27.3) 0 (0) 1 (50.0)
 Sm/RNP 0 (0) 3 (6.5) 2 (6.9) 6 (14.3) 0 (0) 4 (36.4) 1 (5.6) 1 (50.0)
 RNP 0 (0) 6 (13.0) 3 (10.3) 8 (19.0) 2 (18.2) 4 (36.4) 1 (5.6) 1 (50.0)
 Scl-70 0 (0) 1 (2.2) 1 (3.4) 8 (19.0) 1 (9.1) 2 (18.2) 5 (27.8) 0 (0)
 Jo-1 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
 Centromere 0 (0) 1 (2.2) 3 (10.3) 15 (35.7) 0 (0) 1 (9.1) 13 (72.2) 1 (50.0)
 Chromatin 0 (0) 5 (10.9) 2 (6.9) 7 (16.7) 1 (9.1) 5 (45.5) 0 (0) 1 (50.0)
  1. Abbreviations: HC healthy controls, ANS asymptomatic ANA+, UCTD undifferentiated connective tissue disease, SARD systemic autoimmune rheumatic disease, SjD Sjögren’s disease, SLE systemic lupus erythematosus, SSc systemic sclerosis, MCTD mixed connective tissue disease, DM dermatomyositis, dsDNA double-stranded DNA, Sm Smith, RNP ribonuclear protein