Population-specific factors associated with fractional excretion of uric acid

Table 3 Linear regression analysis of 10 single nucleotide polymorphisms with fractional excretion of uric acid

Gene SNP	Eastern Polynesian n = 483					Western Polynesian n = 282					New Zealand European n = 948
Gene SNP	Effect allele freq	β	SE β	Stan. β	P	Effect allele freq	β	SE β	Stan. β	P	Effect allele freq	β	SE β	Stan. β	P
ABCG2 rs2231142	0.102	0.48	0.29	0.07	0.10	0.302	−0.25	0.21	−0.07	0.24	0.195	−0.06	0.15	−0.01	0.70
GCKR rs1260326	0.341	−0.22	0.18	−0.05	0.24	0.266	0.05	0.22	0.01	0.82	0.430	−0.28	0.13	−0.07	0.03
HLF rs7224610	0.192	0.34	0.13	0.11	0.09	0.164	0.44	0.13	0.11	0.01	0.429	0.21	0.19	0.06	0.30
IGF1R rs6598541	0.798	−0.34	0.24	−0.08	0.16	0.888	0.43	0.41	0.08	0.30	0.380	0.06	0.13	0.02	0.64
NFAT5 rs7193778	0.119	−0.15	0.18	−0.03	0.40	0.148	−0.15	0.17	−0.03	0.40	0.835	−0.41	0.25	−0.08	0.11
RREB1 rs675209	0.727	−0.36	0.19	−0.09	0.06	0.885	4.49 × 10⁻³	0.33	0.00	0.99	0.278	−0.09	0.13	0.02	0.51
SLC22A11 rs2078267	0.840	−0.55	0.23	−0.11	0.02	0.945	0.09	0.47	0.01	0.84	0.535	0.03	0.12	0.01	0.80
SLC22A12 rs3825018	0.681	−0.21	0.20	−0.05	0.28	0.710	0.07	0.26	0.02	0.79	0.296	−0.24	0.13	−0.06	0.07
SLC2A9 rs11942223	0.935	−0.80	0.37	−0.10	0.03	0.966	0.86	0.57	0.09	0.13	0.827	−0.86	0.15	−0.17	2.39 × 10⁻⁸
UBE2Q2 rs1394125	0.162	−0.17	0.23	−0.03	0.47	0.056	−0.21	0.45	−0.03	0.63	0.623	0.13	0.12	0.03	0.29

Data adjusted for age and sex. Freq frequency, SE standard error, SNP single nucleotide polymorphism, Stan. standardised

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