|- Know that anti-TNF drugs are the first cause of drug-induced lupus.|
- Do a reference assay of ANA and anti-DNA before starting an anti-TNF.
- Do not monitor these rates in the absence of clinical signs.
- The presence of ANA before treatment does not contraindicate treatment.
- Evoke induced lupus in front of a compatible chronology plus clinical signs and autoantibodies.
- Do not diagnose induced lupus on isolated skin damage in an autoimmune context: a “simple” rash or arthralgia with anti-DNA is not sufficient for diagnosis.
- Always think about looking for visceral signs.
- Stop the product in case of induced lupus and do not take another anti-TNF agent but change class.