Table 2 Correlation of serum biomarkers and SLE disease activity
From: Performance of cytokine models in predicting SLE activity
Biomarker | Active (n = 51) [median (range)] | Inactive (n = 73) [median (range)] | p valueA | R | p valueB |
|---|---|---|---|---|---|
C3, g/l | 0.84 (0.18–1.80) | 0.95 (0.52–1.63) | 0.080 | −0.406 | < 0.001*** |
C4, g/l | 0.17 (0.01–0.69) | 0.22 (0.03–0.47) | 0.528 | −0.203 | 1.000 |
Anti-dsDNA, IU/ml | 64.30 (10.0–800.0) | 24.75 (10.0–800.0) | 0.352 | 0.223 | 1.000 |
IL-1β, pg/ml | 1.39 (1.10–33.97) | 1.39 (1.25–1.39) | 1.000 | 0.126 | 1.000 |
IFN-α, pg/ml | 8.51 (1.48–449.29) | 1.54 (1.48–89.25) | 0.272 | 0.374 | 0.002** |
IFN-γ, pg/ml | 1.52 (1.52–966.81) | 1.58 (1.52–47.24) | 1.000 | 0.126 | 0.223 |
TNF-α, pg/ml | 2.22 (1.90–11.34) | 2.22 (1.22–56.74) | 1.000 | −0.047 | 1.000 |
MCP-1, pg/ml | 1111.96 (330.92–20,499.66) | 609.42 (4.54–14,597.43) | 0.016* | 0.211 | 1.000 |
IL-6, pg/ml | 22.73 (1.27–608.74) | 1.87 (1.00–155.65) | < 0.001*** | 0.450 | < 0.001*** |
IL-8, pg/ml | 70.77 (1.28–840.89) | 16.78 (1.13–220.54) | < 0.001*** | 0.541 | < 0.001*** |
IL-10, pg/ml | 8.96 (1.22–482.23) | 1.42 (1.22–49.32) | 1.000 | 0.103 | 0.101 |
IL-12, pg/ml | 1.06 (1.06–10.61) | 1.06 (1.06–4.52) | 1.000 | 0.108 | 1.000 |
IL-17, pg/ml | 6.34 (1.18–61.96) | 1.47 (1.00–432.93) | 1.000 | 0.062 | 1.000 |
IL-18, pg/ml | 177.87 (1.14–2526.77) | 7.36 (1.14–1288.23) | < 0.001*** | 0.462 | < 0.001*** |
IL-23, pg/ml | 2.52 (2.03–88.94) | 2.52 (2.03–76.62) | 1.000 | 0.046 | 1.000 |
IL-33, pg/ml | 1.66 (0.88–32.29) | 1.66 (1.01–2.19) | 1.000 | −0.009 | 1.000 |