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Table 5 Predictors of SLE disease activity by logistic regression analysis

From: Performance of cytokine models in predicting SLE activity

BiomarkersWeeksModelActive SLE (N = 51)Active renal (N = 31)Active non-renal (N = 20)
ORs (95%CI)p valueORs (95%CI)p valueORs (95%CI)p value
C3 (< 0.9 g/l)0Bivariate2.22 (1.10–4.61)0.0327.90 (2.52–24.74)< 0.0012.12 (0.80–5.64)0.129
Multiple2.33 (0.98–53.5)0.0624.63 (1.48–14.44)0.008
12Bivariate2.52 (1.71–3.69)< 0.0012.82 (1.82–4.37)< 0.0011.25 (0.75–2.07)0.383
Multiple2.54 (1.46–4.42)0.0013.27 (1.69–6.32)< 0.001
C4 (< 0.2 g/l)0Bivariate1.14 (0.53–2.44)0.7387.91 (2.38–26.33)0.0012.01 (0.75–5.36)0.159
Multiple0.82 (0.24–2.78)0.759
12Bivariate2.16 (1.47–3.18)< 0.0012.27 (1.47–3.50)< 0.0011..27 (0.76–2.11)0.354
Multiple1.22 (0.70–2.12)0.4651.08 (0.57–2.07)0.793
Anti-dsDNA (> 100.0 IU/ml)0Bivariate1.87 (0.88–3.98)0.1001.21 (0.43–3.36)0.7141.01 (0.37–2.77)0.974
Multiple
12Bivariate1.10 (0.76–1.59)0.6061.53 (0.99–2.35)0.0530.66 (0.40–1.10)0.116
Multiple
IFN-α (> 10.0 pg/ml)0Bivariate2.23 (1.06–4.68)0.0343.33 (1.13–9.78)0.0281.11 (0.41–2.95)0.833
Multiple0.86 (0.31–2.33)0.7721.39 (0.52–3.69)0.503
12Bivariate1.01 (0.69–1.46)0.9710.99 (0.64–1.51)0.9601.03 (0.62–1.70)0.915
Multiple
MCP-1 (> 960.0 pg/ml)0Bivariate4.08 (1.90–8.73)< 0.0012.09 (0.75–5.84)0.1573.18 (1.13–8.93)0.028
Multiple1.07 (0.36–3.21)0.8931.52 (0.43–5.39)0.510
12Bivariate0.810 (0.56–1.18)0.2690.67 (0.44–1.03)0.0721.17 (0.71–1.95)0.535
Multiple
IL-6 (> 6.2 pg/ml)0Bivariate5.68 (2.26–14.30)< 0.0011.56 (0.50–4.85)0.4394.47 (1.63–12.25)0.004
Multiple3.49 (1.19–19.1)0.0223.11 (1.05–9.26)0.041
12Bivariate0.72 (0.50–1.05)0.0890.77 (0.50–1.19)0.2520.78 (0.47–1.30)0.340
Multiple
IL-8 (> 55.0 pg/ml)0Bivariate7.20 (3.22–16.08)< 0.0013.62 (1.25–10.44)0.0173.09 (1.13–8.42)0.027
Multiple4.86 (1.87–12.57)0.0012.50 (0.87–7.15)0.0861.33 (0.36–4.84)0.657
12Bivariate1.12 (0.77–1.65)0.5670.78 (0.50–1.20)0.2601.81 (1.04–3.17)0.035
Multiple1.81 (1.04–3.17)0.035
IL-18 (> 50.0 pg/ml)0Bivariate9.93 (4.29–22.95)< 0.0017.19 (2.25–22.95)0.0013.31 (1.17–9.29)0.023
Multiple5.54 (12.2–14.43)< 0.0015.37 (1.74–16.57)0.0031.86 (0.55–6.32)0.318
12Bivariate1.55 (1.06–2.27)0.0231.90 (1.20–3.00)0.0060.94 (0.57–1.55)0.802
Multiple1.96 (1.30–2.94)0.0012.53 (1.56–4.14)< 0.001