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Table 5 Proportion of patients experiencing radiographic progression (Δ SHS ≥ 3) within each time interval against categories of diseases activity (time-integrated standardized CRP scores) in the same period

From: Radiographic progression can still occur in individual patients with low or moderate disease activity in the current treat-to-target paradigm: real-world data from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry

Time-integrated inflammation

0–6-month progression

6-months–1-year progression

1-year–2-year progression

2-year–3-year progression

No

Yes

No

Yes

No

Yes

No

Yes

No (CRP ≤ 5)

65 (77.4%)

19 (22.6%)

87 (82.9%)

18 (17.1%)

71 (80.7%)

17 (19.3%)

81 (88.0%)

11 (12.0%)

Mild (CRP > 5 to ≤ 10)

49 (77.8%)

14 (22.2%)

34 (87.2%)

5 (12.8%)

31 (79.5%)

8 (20.5%)

22 (73.3%)

8 (26.7%)

Moderate (CRP > 10 to ≤ 30)

23 (67.6%)

11 (32.4%)

12 (75.0%)

4 (25.0%)

13 (61.9%)

8 (38.1%)

17 (73.9%)

6 (26.1%)

High (CRP > 30)

7 (63.6%)

4 (36.4%)

4 (80.0%)

1 (20.0%)

0 (0.0%)

2 (100%)

1 (50%)

1 (50.0%)

Total

144 (75.0%)

48 (25.0%)

135 (82.8%)

28 (17.2%)

115 (76.7%)

35 (23.3%)

121 (82.3%)

26 (17.7%)