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Table 5 Proportion of patients experiencing radiographic progression (Δ SHS ≥ 3) within each time interval against categories of diseases activity (time-integrated standardized CRP scores) in the same period

From: Radiographic progression can still occur in individual patients with low or moderate disease activity in the current treat-to-target paradigm: real-world data from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry

Time-integrated inflammation0–6-month progression6-months–1-year progression1-year–2-year progression2-year–3-year progression
NoYesNoYesNoYesNoYes
No (CRP ≤ 5)65 (77.4%)19 (22.6%)87 (82.9%)18 (17.1%)71 (80.7%)17 (19.3%)81 (88.0%)11 (12.0%)
Mild (CRP > 5 to ≤ 10)49 (77.8%)14 (22.2%)34 (87.2%)5 (12.8%)31 (79.5%)8 (20.5%)22 (73.3%)8 (26.7%)
Moderate (CRP > 10 to ≤ 30)23 (67.6%)11 (32.4%)12 (75.0%)4 (25.0%)13 (61.9%)8 (38.1%)17 (73.9%)6 (26.1%)
High (CRP > 30)7 (63.6%)4 (36.4%)4 (80.0%)1 (20.0%)0 (0.0%)2 (100%)1 (50%)1 (50.0%)
Total144 (75.0%)48 (25.0%)135 (82.8%)28 (17.2%)115 (76.7%)35 (23.3%)121 (82.3%)26 (17.7%)