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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Long non-coding XIST raises methylation of TIMP-3 promoter to regulate collagen degradation in osteoarthritic chondrocytes after tibial plateau fracture

Fig. 6

Over-expression of TIMP-3 reverses the effect of lncRNA XIST on collagen degradation in chondrocytes. a Relative expression of lncRNA XIST and mRNA expression of TIMP-3 determined by RT-qPCR. b, c The expression of MMP-3, MMP-13, ADAMTS-4, ADAMTS-5, and type II collagen determined by Western blot analysis. * p < 0.05 vs. the oe-NC group (cells transfected with pCMV6-AC-GFP); # p < 0.05 vs. the oe-XIST + oe-NC group (cells transfected with pCMV6-AC-GFP-XIST + pCMV6-AC-GFP); the measurement data were expressed as the mean ± standard deviation, which were analyzed by one-way analysis of variance; the experiment was repeated three times

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