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Table 2 Baseline PRO scores

From: Upadacitinib improves patient-reported outcomes in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying antirheumatic drugs: results from SELECT-NEXT

PRO measures

Baseline, mean ± SD

PBO, n = 221

UPA 15 mg, n = 221

UPA 30 mg, n = 219

PtGA (mm)

60.3 ± 20.5

63.1 ± 21.9

62.8 ± 20.3

Pain VAS (mm)

61.5 ± 20.8

64.1 ± 19.5

64.0 ± 19.8

HAQ-DI

1.4 ± 0.6

1.5 ± 0.6

1.5 ± 0.6

FACIT-F

28.3 ± 11.5

28.1 ± 11.1

27.5 ± 12.6

SF-36 component scores

 PCS

33.1 ± 7.7

33.4 ± 7.4

32.6 ± 7.9

 MCS

46.5 ± 11.7

45.9 ± 10.9

46.1 ± 12.0

SF-36 domainsa

 PF

33.3 ± 9.4

33.5 ± 8.8

32.9 ± 9.7

 RP

35.4 ± 8.1

35.5 ± 8.5

34.7 ± 8.9

 BP

35.3 ± 6.9

35.5 ± 6.4

34.6 ± 6.8

 GH

39.2 ± 9.0

38.9 ± 8.1

39.1 ± 9.4

 VT

41.8 ± 9.0

41.5 ± 9.0

41.2 ± 10.0

 SF

40.8 ± 10.8

40.6 ± 9.9

40.8 ± 11.0

 RE

42.2 ± 11.9

41.1 ± 11.7

41.1 ± 11.9

 MH

43.8 ± 10.7

44.1 ± 9.9

44.0 ± 11.5

SF-6D Utility Index

0.57 ± 0.1

0.57 ± 0.1

0.57 ± 0.1

EQ-5D-5 L Index

0.6 ± 0.2

0.6 ± 0.3

0.6 ± 0.3

EQ-5D VAS (mm)

51.4 ± 21.5

49.6 ± 21.3

49.0 ± 22.0

AM joint stiffness

 Duration (min)

138.9 ± 214.0

152.4 ± 241.9

128.6 ± 156.0

 Severityb

6.1 ± 2.2

6.1 ± 2.4

6.2 ± 2.2

 RA-WISc

12.2 ± 6.1

12.9 ± 5.5

13.5 ± 6.5

  1. AM morning, BP Bodily Pain, CI confidence interval, FACIT-F Functional Assessment of Chronic Illness Therapy-Fatigue, GH General Health, HAQ-DI Health Assessment Questionnaire-Disability Index, LSM least squares mean, MCS mental component summary, MH Mental Health, PBO placebo, PCS physical component summary, PF Physical Functioning, PRO patient-reported outcome, PtGA Patient’s Global Assessment of Disease Activity, RA-WIS Work Instability Scale for RA, RE Role-Emotional, RP Role-Physical, SD standard deviation, SF Social Functioning, SF-36 Short Form 36 Health Survey, UPA upadacitinib, VAS visual analogue scale, VT Vitality
  2. aThe baseline values and LSM changes for SF-36 domains were transformed based on the mean and standard deviation of the 1998 general US population
  3. bAssessed on a numeric scale of 1 to 10, with 10 being the worst level
  4. cCalculated only for employed patients