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Table 2 Baseline PRO scores

From: Upadacitinib improves patient-reported outcomes in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying antirheumatic drugs: results from SELECT-NEXT

PRO measuresBaseline, mean ± SD
PBO, n = 221UPA 15 mg, n = 221UPA 30 mg, n = 219
PtGA (mm)60.3 ± 20.563.1 ± 21.962.8 ± 20.3
Pain VAS (mm)61.5 ± 20.864.1 ± 19.564.0 ± 19.8
HAQ-DI1.4 ± 0.61.5 ± 0.61.5 ± 0.6
FACIT-F28.3 ± 11.528.1 ± 11.127.5 ± 12.6
SF-36 component scores
 PCS33.1 ± 7.733.4 ± 7.432.6 ± 7.9
 MCS46.5 ± 11.745.9 ± 10.946.1 ± 12.0
SF-36 domainsa
 PF33.3 ± 9.433.5 ± 8.832.9 ± 9.7
 RP35.4 ± 8.135.5 ± 8.534.7 ± 8.9
 BP35.3 ± 6.935.5 ± 6.434.6 ± 6.8
 GH39.2 ± 9.038.9 ± 8.139.1 ± 9.4
 VT41.8 ± 9.041.5 ± 9.041.2 ± 10.0
 SF40.8 ± 10.840.6 ± 9.940.8 ± 11.0
 RE42.2 ± 11.941.1 ± 11.741.1 ± 11.9
 MH43.8 ± 10.744.1 ± 9.944.0 ± 11.5
SF-6D Utility Index0.57 ± 0.10.57 ± 0.10.57 ± 0.1
EQ-5D-5 L Index0.6 ± 0.20.6 ± 0.30.6 ± 0.3
EQ-5D VAS (mm)51.4 ± 21.549.6 ± 21.349.0 ± 22.0
AM joint stiffness
 Duration (min)138.9 ± 214.0152.4 ± 241.9128.6 ± 156.0
 Severityb6.1 ± 2.26.1 ± 2.46.2 ± 2.2
 RA-WISc12.2 ± 6.112.9 ± 5.513.5 ± 6.5
  1. AM morning, BP Bodily Pain, CI confidence interval, FACIT-F Functional Assessment of Chronic Illness Therapy-Fatigue, GH General Health, HAQ-DI Health Assessment Questionnaire-Disability Index, LSM least squares mean, MCS mental component summary, MH Mental Health, PBO placebo, PCS physical component summary, PF Physical Functioning, PRO patient-reported outcome, PtGA Patient’s Global Assessment of Disease Activity, RA-WIS Work Instability Scale for RA, RE Role-Emotional, RP Role-Physical, SD standard deviation, SF Social Functioning, SF-36 Short Form 36 Health Survey, UPA upadacitinib, VAS visual analogue scale, VT Vitality
  2. aThe baseline values and LSM changes for SF-36 domains were transformed based on the mean and standard deviation of the 1998 general US population
  3. bAssessed on a numeric scale of 1 to 10, with 10 being the worst level
  4. cCalculated only for employed patients