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Table 3 LSM change (95% CI) from baseline to weeks 4 and 12

From: Upadacitinib improves patient-reported outcomes in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying antirheumatic drugs: results from SELECT-NEXT

PRO measuresWeek 4Week 12
PBO, n = 221UPA 15 mg, n = 221UPA 30 mg, n = 219PBO, n = 221UPA 15 mg, n = 221UPA 30 mg, n = 219
PtGA (mm)− 8.39 (− 11.69, − 5.10)− 20.22 (− 23.57, − 16.87)***− 25.06, (− 28.39, − 21.74)***− 10.36 (− 13.84, − 6.88)− 29.67 (− 33.18, − 26.16)***− 30.51 (− 34.03, − 27.00)***
Pain VAS (mm)− 8.84 (− 12.13, − 5.55)− 20.86 (− 24.21, − 17.52)***− 26.33 (− 29.65, − 23.01)***− 10.26 (− 13.71, − 6.80)− 29.92 (− 33.40, − 26.44)***− 31.71 (− 35.20, − 28.22)***
HAQ-DI− 0.22 (− 0.29, − 0.15)− 0.43 (− 0.50, − 0.36)***− 0.44 (− 0.51, − 0.37)***− 0.26 (− 0.33 to − 0.18)− 0.61 (− 0.68, − 0.53)***− 0.55 (− 0.62, − 0.47)***
FACIT-F2.78 (1.49, 4.06)5.83 (4.52, 7.14)***6.24 (4.94, 7.55)***2.96 (1.62, 4.30)7.91 (6.56, 9.27)***7.74 (6.38, 9.11)***
SF-36 component scores
 PCS2.42 (1.42, 3.42)5.14 (4.12, 6.16)***5.91 (4.89, 6.92)***3.03 (1.88, 4.18)7.58 (6.43, 8.74)***8.01 (6.84, 9.18)***
 MCS2.22 (1.02, 3.42)3.43 (2.21, 4.64)3.19 (1.98, 4.41)2.58 (1.30, 3.87)4.69 (3.40, 5.99)**3.67 (2.36, 4.98)
SF-36 domainsa
 PF2.24 (1.21, 3.26)4.30 (3.25, 5.34)**5.00 (3.96, 6.04)***2.96 (1.80, 4.12)6.92 (5.75, 8.09)***6.81* (5.63, 8.00)***
 RP2.30 (1.23, 3.37)4.17 (3.08, 5.25)**4.92 (3.84, 6.00)***2.88 (1.69, 4.08)6.40 (5.20, 7.61)***6.36 (5.14, 7.58)***
 BP3.49 (2.42, 4.56)6.77 (5.68, 7.86)***8.18 (7.09, 9.26)**4.66 (3.44, 5.88)9.44 (8.21, 10.66)***10.38 (9.14, 11.62)***
 GH1.78 (0.73, 2.82)4.40 (3.33, 5.46)***3.35 (2.29, 4.41)*1.92 (0.78, 3.06)5.61 (4.47, 6.76)***5.00 (3.84, 6.15)***
 VT2.53 (1.36, 3.69)5.14 (3.95, 6.32)***5.58 (4.40, 6.76)***2.52 (1.21, 3.83)6.77 (5.45, 8.09)***7.05 (5.72, 8.38)***
 SF2.30 (1.05, 3.56)3.95 (2.67, 5.23)*3.56 (2.29, 4.83)2.53 (1.24, 3.82)6.17 (4.88, 7.47)***4.81 (3.50, 6.12)**
 RE1.87 (0.60, 3.14)3.56 (2.27, 4.85)*3.32 (2.03, 4.61)2.62 (1.31, 3.94)5.59 (4.26, 6.91)***4.10 (2.76, 5.44)
 MH2.67 (1.54, 3.80)3.61 (2.46, 4.76)4.13 (2.99, 5.28)*3.39 (2.14, 4.63)4.78 (3.53, 6.03)4.77 (3.51, 6.04)
SF-6D Utility Index0.04 (0.02, 0.05)0.06 (0.04, 0.07)*0.07 (0.06, 0.09)***0.04 (0.02, 0.05)0.09 (0.07, 0.10)***0.09 (0.07, 0.10)***
EQ-5D-5 L Index0.07 (0.04, 0.10)0.14 (0.11, 0.17)***0.14 (0.12, 0.17)***0.08 (0.05, 0.11)0.19 (0.16, 0.21)***0.18 (0.16, 0.21)***
EQ-5D VAS (mm)4.25 (1.10, 7.39)9.63 (6.43, 12.83)**14.09 (10.90, 17.28)***5.17 (1.82, 8.53)15.86 (12.48, 19.24)***17.19 (13.78, 20.61)***
AM joint stiffness
 Duration (min)− 21.37 (− 40.31, − 2.43)− 60.73 (− 79.75, − 41.71)**− 63.06 (− 82.06, − 44.06)**− 34.27 (− 54.63, − 13.91)− 85.28 (− 105.61, − 64.95)***− 85.13 (− 105.65, − 64.62)***
 Severityb− 1.03 (− 1.35, − 0.71)− 2.02 (− 2.35, − 1.70)***− 2.48 (− 2.80, − 2.15)***− 1.38 (− 1.73, − 1.03)− 2.88 (− 3.23, − 2.53)***− 3.26 (− 3.61, − 2.90)***
RA-WISc− 1.70 (− 2.78, − 0.62)− 3.08 (− 4.18, − 1.99)*− 2.62 (− 3.80, − 1.44)− 1.55 (− 2.69, − 0.42)− 4.28 (− 5.41, − 3.14)***− 3.48 (− 4.72, − 2.24)**
  1. AM morning, BP Bodily Pain, CI confidence interval, FACIT-F Functional Assessment of Chronic Illness Therapy-Fatigue, GH General Health, HAQ-DI Health Assessment Questionnaire-Disability Index, LSM least squares mean, MCS mental component summary, MH Mental Health, PBO placebo, PCS physical component summary, PF Physical Functioning, PRO patient-reported outcome, PtGA Patient’s Global Assessment of Disease Activity, RA-WIS Work Instability Scale for RA, RE Role-Emotional, RP Role-Physical, SD standard deviation, SF Social Functioning, SF-36 Short Form 36 Health Survey, UPA upadacitinib, VAS visual analogue scale, VT Vitality
  2. ***P < 0.001 for UPA versus PBO
  3. **P < 0.01 for UPA versus PBO
  4. *P < 0.05 for UPA versus PBO
  5. aThe baseline values and LSM changes for SF-36 domains were transformed based on the mean and standard deviation of the 1998 general US population
  6. bAssessed on a numeric scale of 1 to 10, with 10 being the worst level
  7. cCalculated only for employed patients