Fig. 3

Renal histopathologies are attenuated in ALW-treated MRL/lpr mice. a Representative kidney sections (stained with H&E, PAS, Masson, and Ki-67), demonstrating decreased glomerular damage in ALW-treated MRL/lpr mice. b Semiquantitative scored results according to H&E and PAS staining showed significantly decreased glomerular changes (mesangial proliferation, endocapillary hypercellularity, and crescents) in the kidney of ALW-treated mice. c Semiquantitative scoring results due to H&E, PAS, and Masson staining showed a significant difference in tubular injury of ALW-treated mice compared with the NaCl and blank groups, and in interstitial fibrosis between the ALW and blank groups. d Ki-67-stained sections were scored by ImageJ, showing fewer Ki-67-positive cells in both glomerular and tubular areas of ALW-treated mice. Scale bar = 50 μm. *p < 0.05, **p < 0.01, ***p < 0.001