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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: ALW peptide ameliorates lupus nephritis in MRL/lpr mice

Fig. 6

Overview of the effect of ALW peptide on the progress of LN in MRL/lpr mice. After the administration of ALW peptide to MRL/lpr mice, the deposition of IgG, IgG2a, IgG2b, and IgG3 in glomeruli and mesangial cells are significantly reduced, following by alleviated glomerular injury, including mesangial proliferation, endocapillary hypercellularity, and crescents and tubular injury reflected by less tubular atrophy and dilation and fewer casts. At the same time, the infiltration of T cell, B cell, and macrophage cell is inhibited in the kidney of the ALW-treated mice. Renal and serum TGF-β1, PDGF-B, and CTGF accompanied by extracellular matrix (ECM) in the kidney are all declined in ALW-treated mice

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