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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: iNOS dependent and independent phases of lymph node expansion in mice with TNF-induced inflammatory-erosive arthritis

Fig. 3

Cellular accumulations in TNF-Tg sinuses are not affected by genetic iNOS ablation. H and E-stained histology of PLN from female (AE) and male (FJ) mice was investigated to assess if iNOS dependent differences in PLN volume are influenced by cells within the PLN sinuses. Representative images at × 4 (AC, FH) and × 20 (A′C′, F′H′) of WT (A, A′, F, F′), TNF-Tg (B, B′, G, G′), and iNOS−/−× TNF-Tg (C, C′, H, H′) PLN are shown, with histomorphometry (D, E, I, J). Note that the results show that both TNF-Tg and iNOS−/−× TNF-Tg have increased sinus area and numbers of cells within their sinuses compared to WT mice; however, they are not different from each other. Statistical analysis: n = 3–6 per group, one-way ANOVA, ***p < 0.001

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