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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

Fig. 2

Osteoarthritis development in SFZ-specific Ctnnb1-knockout mice. a Safranin O staining and OARSI scores of mouse knee joints of Prg4-CreERT2;Ctnnb1fl/fl and Ctnnb1fl/fl mice 8 weeks after surgery. Tamoxifen induction was performed at 7 weeks. Each experimental group contained nine biologically independent animals. Inset boxes indicate regions of enlarged images below. Scale bars, 50 and 20 μm. *P < 0.05 (Mann-Whitney U test). b Immunostaining of β-catenin (Ctnnb1) and Prg4 in sham knee joints of Prg4-CreERT2;Ctnnb1fl/fl and Ctnnb1fl/fl mice 8 weeks after surgery. Scale bars, 20 μm. c Safranin O staining and OARSI scores of mouse knee joints of Prg4-CreERT2;Ctnnb1fl/fl and Ctnnb1fl/fl mice at 18 months. Tamoxifen induction was performed at 7 weeks. Each experimental group contained six biologically independent animals. Inset boxes indicate regions of enlarged images below. Scale bars, 50 and 20 μm. *P < 0.05 (Mann-Whitney U test)

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