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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

Fig. 4

Regulation of Prg4 expression by Wnt/β-catenin signaling. ac Protein levels of Ctnbn1 and mRNA levels of Prg4, Acan, and Ctnnb1 in SFZ cells derived from a Prg4-CreERT2;Ctnnb1fl/fl mice treated with 4-hydroxytamoxifen (4OHT) or vehicle for 48 h, b Prg4-CreERT2;Ctnnb1-ex3fl/wt mice treated with 4OHT or vehicle for 48 h, or c WT SFZ cells treated with CHIR99021 or vehicle for 48 h. d Immunostaining of Prg4 in mouse femoral heads cultured with CHIR99021 or vehicle for 48 h. Scale bars, 20 μm. All data are expressed as mean ± SD of three biologically independent samples per group. *P < 0.05 versus vehicle (Student’s unpaired two-tailed t test)

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