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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: LNA-anti-miR-150 ameliorated kidney injury of lupus nephritis by inhibiting renal fibrosis and macrophage infiltration

Fig. 3

The effect of LNA-anti-miR-150 on kidney injury in LN mice. a, b Serum ds-DNA titer and urinary albumin/creatinine ratio (ACR) determined by ELISA in WT and LN mice treated with the scrambled LNA or LNA-anti-miR-150 (subcutaneous injection twice weekly for 8 weeks). c PAS staining of paraffin-embedded kidney sections taken from same mice showed glomerular matrix proliferation (arrow, magnification × 400, bar = 200 μm) and the tubulointerstitial infiltration of inflammatory cells (arrowhead, magnification × 200, bar = 200 μm). d Glomerular damages were semi-quantified as a percentage of the injured glomeruli, and e tubulointerstitial infiltrated inflammatory cells were counted per high power field (HPF) on PAS staining. f Masson staining of paraffin-embedded kidney sections taken from experimental mice and the semi-quantification score of sclerotic glomeruli (blue area, magnification × 400, bar = 200 μm). Data are expressed as mean ± SD from six mice per group. Statistical significance was determined using two-way ANOVA (#p < 0.05, LN vs. WT; *p < 0.05, LNA-anti-miR-150 vs. the scrambled LNA)

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