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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: LNA-anti-miR-150 ameliorated kidney injury of lupus nephritis by inhibiting renal fibrosis and macrophage infiltration

Fig. 7

miR-150 expression in the renal biopsies from LN patients. In kidney biopsies from LN patients and normal control kidneys (NC), a the renal distribution of miR-150 stained by in situ hybridization (arrows, magnification × 100, bar = 100 μm) and b renal expression levels of miR-150 determined by qPCR; c the immunohistochemistry staining of fibrotic-related proteins including pro-fibrotic proteins (TGF-β1, α-SMA, and FN), anti-fibrotic protein SOCS1, and the infiltration of macrophages indicated F4/80 (arrow) and CD68 (positive tubulointerstitial CD68 in insert panel) as well as the percentage of positive staining of each above protein. Data are expressed as mean ± SD from ten subjects per group. Statistical significance was determined using t test (#p < 0.05, LN vs. NC, magnification × 200, bar = 50 μm)

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