Fig. 1

Longitudinal monitoring of inflammation, pain, and locomotor deficits in collagen-induced arthritis (CIA) mice. a Paw swelling (squares) and skin temperature (circles) compared in CIA mice (closed symbols) and naïve (non-immunized, open symbols) mice over time (n = 8). b Hind paw clinical score (squares) and latency before withdrawal (thermal nociception) measured with the Hargreaves test (circles) over time (n = 8). c Total clinical score (squares) and distance traveled in the open field test for 10 min (circles) (n = 8). d Hind paw clinical score (squares) and hind paw area (Catwalk™) (circles) (n = 8). Data were compared between CIA (closed symbols) and naïve (open symbols) mice at the same time point with the repeated two-way ANOVA test followed by Sidak’s multiple comparison test. The asterisk symbol is used for the comparison of paw swelling or clinical score between CIA and naïve mice, the dollar sign is used for the comparison of functional parameter (skin temperature, latency before withdrawal, distance traveled, or print area) between CIA and naïve mice. ^*,$p < 0.05, **^,$$p < 0.01, ***^,$$$p < 0.001