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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy and autoimmunity

Fig. 4

Increased collagen fibers density in the lung and skin and increase expression of endothelial markers of vascular injury in mice following the immunization with Col V. Quantification of collagen I (Col I), collagen III (Col III), and collagen V (Col V) and endothelial markers in the lung (a) and Col I, Col III, and Col V in the skin (b) by Image Pro-Plus of mice immunized with Col V. The quantification of the Picrosirius staining showed collagen fine fibers increase in Col V-immunized mice compared with control. Data are mean ± s.e. (n = 38) P < 0.05

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