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Table 4 Correlations between antibody levels in serum (upper part) and IC (lower part) vs. SLEDAI-2K in 55 belimumab-treated SLE patients

From: Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus

 MonthsdsDNAHistoneRib PPCNASSA/Ro52SSA/Ro60SSB/LaSmU1
RNP
Sm-U1
RNP
Serum00.350 (0.010)0.036 (0.798)0.230 (0.098)0.059 (0.675)− 0.086 (0.541)− 0.077 (0.582)− 0.082 (0.561)0.272 (0.049)0.105 (0.454)0.235 (0.091)
0–30.586 (0.723)− 0.076 (0.644)0.223 (0.173)0.253 (0.120)0.156 (0.344)0.326 (0.105)0.210 (0.200)0.139 (0.398)0.264 (0.104)0.181 (0.272)
0–60.055 (0.776)0.009 (0.963)0.206 (0.283)− 0.253 (0.204)− 0.128 (0.507)0.076 (0.696)− 0.175 (0.364)0.160 (0.408)0.003 (0.987)0.159 (0.409)
0–120.355 (0.089)0.347 (0.097)0.029 (0.893)0.129 (0.549)0.054 (0.803)0.277 (0.190)0.186 (0.386)− 0.009 (0.968)− 0.033 (0879)0.071 (0.742)
0–240.400 (0.081)0.141 (0.553)0.458 (0.042)0.542 (0.014)0.045 (0.850)0.323 (0.166)0.276 (0.239)0.518 (0.019)0.648 (0.002)0.565 (0.009)
IC00.139 (0.320)0.123 (0.379)− 0.087 (0.535)− 0.023 (0.870)0.040 (0.776)− 0.042 (0.765)0.103 (0.464)0.194 (0.164)0.057 (0.687)0.129 (0.358)
0–30.002 (0.989)0.093 (0.575)0.103 (0.533)0.105 (0.524)0.328 (0.042)0.040 (0.847)0.281 (0.084)− 0.034 (0.839)0.056 (0.734)0.153 (0.352)
0–60.037 (0.848)0.150 (0.439)0.034 (0.863)− 0.235 (0.238)0.187 (0.332)0.135 (0.485)0.185 (0.336)− 0.003 (0.988)0.209 (0.276)0.145 (0.452)
0–120.389 (0.060)0.231 (0.277)− 0.144 (0.502)0.112 (0.603)0.260 (0.221)0.248 (0.242)0.285 (0.177)0.066 (0.760)0.180 (0.401)0.137 (0.524)
0–240.200 (0.412)0.071 (0.774)− 0.311 (0.195)− 0.045 (0.857)0.058 (0.813)0.138 (0.572)0.126 (0.608)0.247 (0.308)0.128 (0.602)0.008 (0.976)
  1. SLEDAI-2K values including complement and centrally measured anti-dsDNA were used. In the first rows for each compartment, baseline autoantibody levels are compared with baselined SLEDAI-2K. In the following rows, changes in autoantibody levels in serum or IC during 3-, 6-, 12-, and 24-month follow-up and changes in SLEDAI-2K during the corresponding periods are compared. Spearman’s ρ coefficients are shown, with corresponding p values within brackets. Significant correlations are depicted in italics. Rib P ribosomal P