Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus

Azita Sohrabian; Ioannis Parodis; Nellie Carlströmer-Berthén; Martina Frodlund; Andreas Jönsen; Agneta Zickert; Christopher Sjöwall; Anders A. Bengtsson; Iva Gunnarsson; Johan Rönnelid

doi:10.1186/s13075-019-2056-y

Table 4 Correlations between antibody levels in serum (upper part) and IC (lower part) vs. SLEDAI-2K in 55 belimumab-treated SLE patients

From: Increased levels of anti-dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus

	Months	dsDNA	Histone	Rib P	PCNA	SSA/Ro52	SSA/Ro60	SSB/La	Sm	U1 RNP	Sm-U1 RNP
Serum	0	0.350 (0.010)	0.036 (0.798)	0.230 (0.098)	0.059 (0.675)	− 0.086 (0.541)	− 0.077 (0.582)	− 0.082 (0.561)	0.272 (0.049)	0.105 (0.454)	0.235 (0.091)
	0–3	0.586 (0.723)	− 0.076 (0.644)	0.223 (0.173)	0.253 (0.120)	0.156 (0.344)	0.326 (0.105)	0.210 (0.200)	0.139 (0.398)	0.264 (0.104)	0.181 (0.272)
	0–6	0.055 (0.776)	0.009 (0.963)	0.206 (0.283)	− 0.253 (0.204)	− 0.128 (0.507)	0.076 (0.696)	− 0.175 (0.364)	0.160 (0.408)	0.003 (0.987)	0.159 (0.409)
	0–12	0.355 (0.089)	0.347 (0.097)	0.029 (0.893)	0.129 (0.549)	0.054 (0.803)	0.277 (0.190)	0.186 (0.386)	− 0.009 (0.968)	− 0.033 (0879)	0.071 (0.742)
	0–24	0.400 (0.081)	0.141 (0.553)	0.458 (0.042)	0.542 (0.014)	0.045 (0.850)	0.323 (0.166)	0.276 (0.239)	0.518 (0.019)	0.648 (0.002)	0.565 (0.009)
IC	0	0.139 (0.320)	0.123 (0.379)	− 0.087 (0.535)	− 0.023 (0.870)	0.040 (0.776)	− 0.042 (0.765)	0.103 (0.464)	0.194 (0.164)	0.057 (0.687)	0.129 (0.358)
	0–3	0.002 (0.989)	0.093 (0.575)	0.103 (0.533)	0.105 (0.524)	0.328 (0.042)	0.040 (0.847)	0.281 (0.084)	− 0.034 (0.839)	0.056 (0.734)	0.153 (0.352)
	0–6	0.037 (0.848)	0.150 (0.439)	0.034 (0.863)	− 0.235 (0.238)	0.187 (0.332)	0.135 (0.485)	0.185 (0.336)	− 0.003 (0.988)	0.209 (0.276)	0.145 (0.452)
	0–12	0.389 (0.060)	0.231 (0.277)	− 0.144 (0.502)	0.112 (0.603)	0.260 (0.221)	0.248 (0.242)	0.285 (0.177)	0.066 (0.760)	0.180 (0.401)	0.137 (0.524)
	0–24	0.200 (0.412)	0.071 (0.774)	− 0.311 (0.195)	− 0.045 (0.857)	0.058 (0.813)	0.138 (0.572)	0.126 (0.608)	0.247 (0.308)	0.128 (0.602)	0.008 (0.976)

SLEDAI-2K values including complement and centrally measured anti-dsDNA were used. In the first rows for each compartment, baseline autoantibody levels are compared with baselined SLEDAI-2K. In the following rows, changes in autoantibody levels in serum or IC during 3-, 6-, 12-, and 24-month follow-up and changes in SLEDAI-2K during the corresponding periods are compared. Spearman’s ρ coefficients are shown, with corresponding p values within brackets. Significant correlations are depicted in italics. Rib P ribosomal P

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