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Table 2 Clinical parameters (maximum mouth’s opening, distance between upper and lower incisors, inter-commissural distance, upper and lower lip’s thickness), expressed as mean ± SD at baseline (T0), during the third injection (T1), the 1-month follow-up (T2), the 3-month follow-up (T3), and the 24-month follow-up (T4)

From: Hyaluronic acid and platelet-rich plasma, a new therapeutic alternative for scleroderma patients: a prospective open-label study

 Baseline (T0)1 month (T1)2 months (T2)3 months (T3)24 months (T4)Comparison to the baselineANOVAFriedman test
Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)p valueFp valueTest Stat. Appr.p value
T0/T3T0/T4
Maximum mouth’s opening (mm)47.61 (4.56)50.91 (6.47)50.35 (6.19)49.23 (5.27)48.60 (5.30)0.00590.009311.480.001530.45< 0.0001
Distance between upper and lower incisors (mm)27.05 (5.80)30.65 (5.71)30.41 (5.90)29.03 (5.65)28.14 (5.61)0.00510.006922.36< 0.000133.04< 0.0001
Inter-commissural distance (mm)49.12 (1.55)51.54 (3.01)53.43 (2.79)51.44 (2.47)50.31 (2.02)0.00580.006523.68< 0.000132.50< 0.0001
Upper lip’s thickness (mm)4.20 (1.54)5.25 (1.62)5.65 (1.52)4.75 (1.35)4.45 (1.32)0.01540.1519.64< 0.000129.52< 0.0001
Lower lip’s thickness (mm)3.80 (1.87)5.10 (2.13)5.75 (1.87)4.85 (1.81)4.25 (1.85)0.00410.016322.98< 0.000131.15< 0.0001