Fig. 4

Uni- (a) and multivariable (b) analyses for the association between weight change and loss of tibial cartilage volume. Bar graph indicates the mean value of tibial cartilage loss (%/year), and error bars indicate standard errors. Multivariable analyses adjusted for age, sex, body mass index, radiographic osteoarthritis, history of knee surgery and knee injury, physical activity and site-specific tibial cartilage volume at baseline