Association of age, sex and BMI with the rate of change in tibial cartilage volume: a 10.7-year longitudinal cohort study

Table 2 Association of age and sex with tibial cartilage volume change over 10.7 years

	Multivariable, β (95% CI)			Interaction with sex (male vs. female)	p for interaction
	Females (n = 211)^†	Males (n = 217)^†	Combined (n = 428)^‡	Interaction with sex (male vs. female)	p for interaction
Loss of cartilage volume (mm³/year)
Medial tibial	0.27 (0.00 to 0.54)	0.43 (0.14 to 0.73)	0.36 (0.16 to 0.57)	0.16 (− 0.24 to 0.57)	0.430
Lateral tibial	0.37 (0.11 to 0.63)	0.04 (− 0.27 to 0.34)	0.18 (− 0.02 to 0.38)	− 0.33 (− 0.73 to 0.07)	0.107
Total tibial	0.66 (0.24 to 1.07)	0.49 (0.05 to 0.92)	0.56 (0.26 to 0.86)	− 0.17 (− 0.78 to 0.43)	0.575
Loss of cartilage volume (%/year)
Medial tibial	0.023 (0.003 to 0.043)	0.023 (0.006 to 0.041)	0.023 (0.010 to 0.036)	0.000 (− 0.026 to 0.027)	0.980
Lateral tibial	0.025 (0.009 to 0.041)	0.002 (− 0.010 to 0.015)	0.013 (0.003 to 0.023)	− 0.023 (− 0.043 to − 0.003)	0.024
Total tibial	0.024 (0.010 to 0.038)	0.012 (0.002 to 0.022)	0.018 (0.009 to 0.026)	− 0.012 (− 0.029 to 0.005)	0.173

^†Model 1: adjusted for body mass index, radiographic osteoarthritis, history of knee surgery and knee injury, physical activity and site-specific tibial cartilage volume at baseline
^‡Model 1 + sex
Italicised data denotes statistically significant result

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