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Table 2 Association of age and sex with tibial cartilage volume change over 10.7 years

From: Association of age, sex and BMI with the rate of change in tibial cartilage volume: a 10.7-year longitudinal cohort study

 Multivariable, β (95% CI)Interaction with sex (male vs. female)p for interaction
Females (n = 211)Males (n = 217)Combined (n = 428)
Loss of cartilage volume (mm3/year)
 Medial tibial0.27 (0.00 to 0.54)0.43 (0.14 to 0.73)0.36 (0.16 to 0.57)0.16 (− 0.24 to 0.57)0.430
 Lateral tibial0.37 (0.11 to 0.63)0.04 (− 0.27 to 0.34)0.18 (− 0.02 to 0.38)− 0.33 (− 0.73 to 0.07)0.107
 Total tibial0.66 (0.24 to 1.07)0.49 (0.05 to 0.92)0.56 (0.26 to 0.86)− 0.17 (− 0.78 to 0.43)0.575
Loss of cartilage volume (%/year)
 Medial tibial0.023 (0.003 to 0.043)0.023 (0.006 to 0.041)0.023 (0.010 to 0.036)0.000 (− 0.026 to 0.027)0.980
 Lateral tibial0.025 (0.009 to 0.041)0.002 (− 0.010 to 0.015)0.013 (0.003 to 0.023)− 0.023 (− 0.043 to − 0.003)0.024
 Total tibial0.024 (0.010 to 0.038)0.012 (0.002 to 0.022)0.018 (0.009 to 0.026)− 0.012 (− 0.029 to 0.005)0.173
  1. Model 1: adjusted for body mass index, radiographic osteoarthritis, history of knee surgery and knee injury, physical activity and site-specific tibial cartilage volume at baseline
  2. Model 1 + sex
  3. Italicised data denotes statistically significant result