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Table 5 Diagnostic efficiencies of combined biomarkers of LNA

From: Diagnostic performance of serum cystatin C and complement component 1q in lupus nephritis

ItemsAUC (95%CI)Z/PaSe (%)Sp (%)YIZ/Pb
C1q + eGFRCreat0.756 (0.725~0.785)13.926/0.00051.292.20.43412.196/0.000
C1q + Creat0.765 (0.735~0.794)4.587/0.00057.588.90.46411.864/0.000
C1q + Urea0.805 (0.776~0.831)18.108/0.00062.089.90.51910.627/0.000
C1q + CysC0.933 (0.914~0.949)46.787/0.00082.992.60.7556.172/0.000
C1q + Urea + eGFRCreat0.813 (0.785~0.839)8.969/0.00070.781.70.52410.309/0.000
C1q + Urea + CysC0.934 (0.915~0.950)46.787/0.00082.992.60.7556.182/0.000
Urea + CysC + eGFRCreat0.959 (0.943~0.971)67.443/0.00087.793.20.8094.178/0.000
C1q + CysC + eGFRCreat0.969 (0.955~0.980)79.306/0.00092.890.70.8363.802/0.001
Urea + CysC + eGFRCreat + Creat0.964 (0.949~0.976)73.979/0.00090.491.80.8223.053/0.002
C1q + Urea + CysC + eGFRCreat0.969 (0.955~0.980)79.306/0.00092.890.70.8363.897/0.001
C1q + CysC + eGFRCreat + Creat0.974 (0.961~0.984)88.822/0.00091.095.00.8601.016/0.310
C1q + Urea + CysC + eGFRCreat + Creat0.975 (0.962~0.984)88.976/0.00092.594.40.869
  1. Receiver operating characteristic (ROC) curve was applied to identify the diagnostic efficiencies of combined multiple indicators
  2. Z was the statistics of DeLong non-parametric test to evaluate the statistical difference between the two AUCs
  3. Creat creatinine, Urea urea, C1q complement component 1q, CysC cystatin C
  4. aZ and P values were the AUC-based statistics of each item
  5. bZ and P values were the AUC-based statistics of each item in comparison with the joint utilization of C1q, Urea, CysC, eGFRCreat, and Creat