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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis

Fig. 4

The ten AGS proteins identified in the hallmark gene sets apical junction, epithelial-mesenchymal transition, and TGF-beta signaling in pre-symptomatic individuals and RA patients. a Protein abundance levels (log10) in controls vs. pre-symptomatic individuals; the upper panel shows proteins related to apical junction, the middle panel shows proteins related to epithelial-mesenchymal transition, and the lower panel shows proteins related to the TGF-beta signaling gene set in pre-symptomatic individuals (n = 118, using only the sample collected closest to symptom onset) and RA patients (n = 74). bd Subnetworks extracted from the global Pathway Commons network: links connecting AGS proteins (yellow) with proteins of the b apical junction, c epithelial-mesenchymal transition, and d TGF-beta signaling gene sets. Only S100A12.1 with the most significant results is included in graphs b and c

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