Fig. 4
The ten AGS proteins identified in the hallmark gene sets apical junction, epithelial-mesenchymal transition, and TGF-beta signaling in pre-symptomatic individuals and RA patients. a Protein abundance levels (log10) in controls vs. pre-symptomatic individuals; the upper panel shows proteins related to apical junction, the middle panel shows proteins related to epithelial-mesenchymal transition, and the lower panel shows proteins related to the TGF-beta signaling gene set in pre-symptomatic individuals (n = 118, using only the sample collected closest to symptom onset) and RA patients (n = 74). b–d Subnetworks extracted from the global Pathway Commons network: links connecting AGS proteins (yellow) with proteins of the b apical junction, c epithelial-mesenchymal transition, and d TGF-beta signaling gene sets. Only S100A12.1 with the most significant results is included in graphs b and c