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Table 1 The ten proteins with the highest significance using multifactorial linear regression for pre-symptomatic individuals, RA patients, and controls compared two-by-two

From: Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis

Pre-symptomatic individuals vs. controls
 Proteinp valueUp or downregulateda
  TNF1.94E−07
  PRR162.68E−07
  CSF22.05E−06
  CCDC85C2.91E−06
  CASP83.72E−06
  IL335.45E−06
  FAM81A5.77E−06
  SELE8.44E−06
  HTRA11.39E−05
  MMP102.16E−05
Patients vs. controls
 Proteinp valueUp or downregulateda
  TNF5.52E−26
  PRR169.82E−26
  S100A121.06E−24
  CSF23.33E−24
  CASP82.35E−23
  FAM81A6.74E−22
  MMP101.56E−21
  HTRA12.05E−20
  SELE2.30E−20
  ORM1, ORM25.80E−20
Pre-symptomatic individuals vs. patients
 Proteinp valueUp or downregulatedb
  KCNB22.92E−04
  S100A127.41E−04
  EPB41L51.97E−03
  COL6A12.55E−03
  ZNF6183.82E−03
  S100A124.32E−03
  TGFB34.43E−03
  CCDC85C6.28E−03
  CSF26.73E−03
  DSC36.90E−03
  SLC11A18.33E−03
  1. Protein included uniquely in one of three top ten protein lists. An expression change based comparison in apre-symptomatic individuals or RA patients vs. controls and bRA patients vs. pre-symptomatic individuals
  2. CASP8 caspase 8; CCDC85C coiled-coil domain containing 85C; COL6A1 collagen type VI alpha 1 chain; CSF2 colony-stimulating factor 2; DSC3 desmocollin 3; EPB41L5 erythrocyte membrane protein band 4.1 like 5; FAM81A family with sequence similarity 81 member A; HTRA1 HtrA serine peptidase 1; IL33 interleukin 33; KCNB2 potassium voltage-gated channel subfamily B member 2; MMP10 matrix metallopeptidase 10; ORM1, ORM2 orosomucoid 1, orosomucoid 2; PRR16 proline rich 16; S100A12 S100 calcium-binding protein A12; SELE selectin E; SLC11A1 solute carrier family 11 member 1; TGFB3 transforming growth factor beta 3; TNF tumor necrosis factor; ZNF618 zinc finger protein 618