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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Unique primed status of microglia under the systemic autoimmune condition of lupus-prone mice

Fig. 4

Further classification and analysis of CD11b+ myeloid cells. a Representative plots of brain CD11b+ myeloid cells in lupus model mice and their controls. They were classified into four populations. a (dendritic cells and macrophages): MHC IIhiLy6Clo cells, b (Ly6Clo monocytes): MHC IIloLy6Clo cells, c (Ly6Chi monocytes): MHC IIloLy6Chi cells, and d (granulocytes): MHC IIloLy6Cint cells. b Representative plots of Ly6G expression, side scatter (SSC) and CD11c expression in CD11b+ myeloid cells from FcγRIIB−/−Yaa mice. High Ly6G and high SSC in population “d” indicate their granulocyte character. c Numbers of dendritic cells and macrophages (a), Ly6Clo monocytes (b), Ly6Chi monocytes (c), and granulocytes (d) in three lupus models. In c, symbols represent individual mice (n = 6 for FcγRIIB−/−Yaa mice and controls, n = 6 for NZB/NZW mice and controls, n = 4 for MRL/lpr mice and controls) and horizontal lines indicate the mean and SEM. *P < 0.05, **P < 0.01, and ***P < 0.01 by Student’s t test

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