Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Comparison of peripheral immune cells among GCA, TAK, and HCs

From: Significant association between clinical characteristics and changes in peripheral immuno-phenotype in large vessel vasculitis

Immune cell subtype (cells per μL)GCA, n = 12TAK, n = 8HC for GCA, n = 5HC for TAK, n = 5ANOVAPost hoc test
p valueGCA vs TAKGCA vs HCTAK vs HC
CD4+ T491 ± 207621 ± 282512 ± 203383 ± 2310.36   
 CD4 HLA-DR+16 ± 8.911 ± 3.28.5 ± 0.807.6 ± 5.10.074   
 CD4 naive214 ± 38248 ± 47270 ± 66210 ± 590.85   
 CD4 Teff5.1 ± 4.526 ± 535.4 ± 3.218 ± 210.46   
 CD4 Tcm194 ± 96220 ± 90143 ± 33121 ± 710.18   
 CD4 Tem78 ± 49128 ± 8366 ± 1.077 ± 290.18   
 Th180 ± 42114 ± 1862 ± 6.162 ± 300.23   
 Th1 HLA-DR+25 ± 1418 ± 199.3 ± 3.113 ± 110.22   
 Th240 ± 2028 ± 1820 ± 9.719 ± 180.10   
 Th2 HLA-DR+6.4 ± 1.63.0 ± 2.22.1 ± 1.03.1 ± 1.90.13   
 Th1757 ± 3878 ± 3336 ± 1431 ± 140.061   
 Th17 HLA-DR+9.9 ± 8.510 ± 5.04.0 ± 1.95.1 ± 4.10.26   
 Treg20 ± 1225 ± 1611 ± 5.912 ± 5.30.16   
 Treg HLA-DR+8.9 ± 7.27.8 ± 4.25.0 ± 1.03.1 ± 1.50.20   
 Tfh68 ± 2987 ± 3163 ± 2036 ± 210.0250.430.980.014
 Tfh116 ± 8.825 ± 3.315 ± 0.911 ± 4.90.063   
 Tfh28.3 ± 5.09.1 ± 8.84.1 ± 1.15.2 ± 3.60.41   
 Tfh1724 ± 1129 ± 9.823 ± 1010 ± 7.60.0350.210.990.057
 Tfr5.1 ± 2.55.6 ± 3.53.7 ± 0.142.6 ± 2.60.23   
CD8+ T189 ± 115331 ± 128228 ± 126163 ± 520.0390.0440.930.033
 CD8 HLA-DR+24 ± 2216 ± 9.65.6 ± 2.66.6 ± 4.10.12   
 CD8 naive23 ± 1777 ± 5094 ± 6174 ± 190.0150.0540.0430.99
 CD8 Teff90 ± 8998 ± 5230 ± 1243 ± 230.24   
 CD8 Tcm20 ± 1328 ± 219.9 ± 4.612 ± 6.60.15   
 CD8 Tem57 ± 35128 ± 8754 ± 2351 ± 150.0240.0280.990.033
γδT5.5 ± 5.122 ± 264.7 ± 1.718 ± 320.22   
NKT29 ± 3343 ± 343.7 ± 0.729 ± 130.22   
CD19+ B97 ± 51211 ± 175226 ± 8994 ± 420.0450.110.170.23
 CD27 IgD+ naive B79 ± 48161 ± 151186 ± 7752 ± 130.052   
 CD27 IgD+ activated B2.4 ± 1.66.7 ± 5.313 ± 4.813 ± 110.00380.350.0170.29
 CD27+ IgD memory B11 ± 5.831 ± 2018 ± 3.916 ± 120.0150.00860.740.17
 Plasmablast0.6 ± 0.83.3 ± 5.30.2 ± 0.060.9 ± 1.00.17   
 Plasma cell0.5 ± 0.52.1 ± 3.40.05 ± 0.00.3 ± 0.40.17   
NK171 ± 170149 ± 77123 ± 6.4153 ± 480.92   
DC14 ± 9.717 ± 1421 ± 3.719 ± 150.72   
 mDC8.2 ± 5.86.6 ± 2.315 ± 1.411 ± 5.40.0350.880.0710.43
 pDC1.3 ± 1.02.2 ± 1.43.2 ± 1.74.5 ± 6.40.20   
Monocyte209 ± 91258 ± 3093 ± 43158 ± 380.0240.590.110.020
 CD14++ CD16144 ± 73188 ± 9480 ± 4.3116 ± 350.096   
 CD14++ CD16+48 ± 3644 ± 225.3 ± 0.520 ± 150.0400.980.0490.30
 CD14+ CD16+11 ± 7.016 ± 7.34.5 ± 3.512 ± 3.10.084   
Eosinophil76 ± 36135 ± 11550 ± 4063 ± 450.14   
Neutrophil4009 ± 20544329 ± 24251232 ± 6881551 ± 7590.0130.980.0730.036
Basophil30 ± 2535 ± 1430 ± 0.126 ± 260.90   
  1. Comparison between of baseline peripheral immune cell number between GCA (n = 12), TAK (n = 8), HC for GCA (n = 5), and HC for TAK (n = 5) using ANOVA and post hoc test
  2. Th helper T, Tfh follicular helper T, NK natural killer, DC dendritic cell, mDC myeloid DC, pDC plasmacytoid DC