Immune cell subtype (cells per μL) | GCA, n = 12 | TAK, n = 8 | HC for GCA, n = 5 | HC for TAK, n = 5 | ANOVA | Post hoc test | ||
---|---|---|---|---|---|---|---|---|
p value | GCA vs TAK | GCA vs HC | TAK vs HC | |||||
CD4+ T | 491 ± 207 | 621 ± 282 | 512 ± 203 | 383 ± 231 | 0.36 |  |  |  |
 CD4 HLA-DR+ | 16 ± 8.9 | 11 ± 3.2 | 8.5 ± 0.80 | 7.6 ± 5.1 | 0.074 |  |  |  |
 CD4 naive | 214 ± 38 | 248 ± 47 | 270 ± 66 | 210 ± 59 | 0.85 |  |  |  |
 CD4 Teff | 5.1 ± 4.5 | 26 ± 53 | 5.4 ± 3.2 | 18 ± 21 | 0.46 |  |  |  |
 CD4 Tcm | 194 ± 96 | 220 ± 90 | 143 ± 33 | 121 ± 71 | 0.18 |  |  |  |
 CD4 Tem | 78 ± 49 | 128 ± 83 | 66 ± 1.0 | 77 ± 29 | 0.18 |  |  |  |
 Th1 | 80 ± 42 | 114 ± 18 | 62 ± 6.1 | 62 ± 30 | 0.23 |  |  |  |
 Th1 HLA-DR+ | 25 ± 14 | 18 ± 19 | 9.3 ± 3.1 | 13 ± 11 | 0.22 |  |  |  |
 Th2 | 40 ± 20 | 28 ± 18 | 20 ± 9.7 | 19 ± 18 | 0.10 |  |  |  |
 Th2 HLA-DR+ | 6.4 ± 1.6 | 3.0 ± 2.2 | 2.1 ± 1.0 | 3.1 ± 1.9 | 0.13 |  |  |  |
 Th17 | 57 ± 38 | 78 ± 33 | 36 ± 14 | 31 ± 14 | 0.061 |  |  |  |
 Th17 HLA-DR+ | 9.9 ± 8.5 | 10 ± 5.0 | 4.0 ± 1.9 | 5.1 ± 4.1 | 0.26 |  |  |  |
 Treg | 20 ± 12 | 25 ± 16 | 11 ± 5.9 | 12 ± 5.3 | 0.16 |  |  |  |
 Treg HLA-DR+ | 8.9 ± 7.2 | 7.8 ± 4.2 | 5.0 ± 1.0 | 3.1 ± 1.5 | 0.20 |  |  |  |
 Tfh | 68 ± 29 | 87 ± 31 | 63 ± 20 | 36 ± 21 | 0.025 | 0.43 | 0.98 | 0.014 |
 Tfh1 | 16 ± 8.8 | 25 ± 3.3 | 15 ± 0.9 | 11 ± 4.9 | 0.063 |  |  |  |
 Tfh2 | 8.3 ± 5.0 | 9.1 ± 8.8 | 4.1 ± 1.1 | 5.2 ± 3.6 | 0.41 |  |  |  |
 Tfh17 | 24 ± 11 | 29 ± 9.8 | 23 ± 10 | 10 ± 7.6 | 0.035 | 0.21 | 0.99 | 0.057 |
 Tfr | 5.1 ± 2.5 | 5.6 ± 3.5 | 3.7 ± 0.14 | 2.6 ± 2.6 | 0.23 |  |  |  |
CD8+ T | 189 ± 115 | 331 ± 128 | 228 ± 126 | 163 ± 52 | 0.039 | 0.044 | 0.93 | 0.033 |
 CD8 HLA-DR+ | 24 ± 22 | 16 ± 9.6 | 5.6 ± 2.6 | 6.6 ± 4.1 | 0.12 |  |  |  |
 CD8 naive | 23 ± 17 | 77 ± 50 | 94 ± 61 | 74 ± 19 | 0.015 | 0.054 | 0.043 | 0.99 |
 CD8 Teff | 90 ± 89 | 98 ± 52 | 30 ± 12 | 43 ± 23 | 0.24 |  |  |  |
 CD8 Tcm | 20 ± 13 | 28 ± 21 | 9.9 ± 4.6 | 12 ± 6.6 | 0.15 |  |  |  |
 CD8 Tem | 57 ± 35 | 128 ± 87 | 54 ± 23 | 51 ± 15 | 0.024 | 0.028 | 0.99 | 0.033 |
γδT | 5.5 ± 5.1 | 22 ± 26 | 4.7 ± 1.7 | 18 ± 32 | 0.22 |  |  |  |
NKT | 29 ± 33 | 43 ± 34 | 3.7 ± 0.7 | 29 ± 13 | 0.22 |  |  |  |
CD19+ B | 97 ± 51 | 211 ± 175 | 226 ± 89 | 94 ± 42 | 0.045 | 0.11 | 0.17 | 0.23 |
 CD27− IgD+ naive B | 79 ± 48 | 161 ± 151 | 186 ± 77 | 52 ± 13 | 0.052 |  |  |  |
 CD27− IgD+ activated B | 2.4 ± 1.6 | 6.7 ± 5.3 | 13 ± 4.8 | 13 ± 11 | 0.0038 | 0.35 | 0.017 | 0.29 |
 CD27+ IgD− memory B | 11 ± 5.8 | 31 ± 20 | 18 ± 3.9 | 16 ± 12 | 0.015 | 0.0086 | 0.74 | 0.17 |
 Plasmablast | 0.6 ± 0.8 | 3.3 ± 5.3 | 0.2 ± 0.06 | 0.9 ± 1.0 | 0.17 |  |  |  |
 Plasma cell | 0.5 ± 0.5 | 2.1 ± 3.4 | 0.05 ± 0.0 | 0.3 ± 0.4 | 0.17 |  |  |  |
NK | 171 ± 170 | 149 ± 77 | 123 ± 6.4 | 153 ± 48 | 0.92 |  |  |  |
DC | 14 ± 9.7 | 17 ± 14 | 21 ± 3.7 | 19 ± 15 | 0.72 |  |  |  |
 mDC | 8.2 ± 5.8 | 6.6 ± 2.3 | 15 ± 1.4 | 11 ± 5.4 | 0.035 | 0.88 | 0.071 | 0.43 |
 pDC | 1.3 ± 1.0 | 2.2 ± 1.4 | 3.2 ± 1.7 | 4.5 ± 6.4 | 0.20 |  |  |  |
Monocyte | 209 ± 91 | 258 ± 30 | 93 ± 43 | 158 ± 38 | 0.024 | 0.59 | 0.11 | 0.020 |
 CD14++ CD16− | 144 ± 73 | 188 ± 94 | 80 ± 4.3 | 116 ± 35 | 0.096 |  |  |  |
 CD14++ CD16+ | 48 ± 36 | 44 ± 22 | 5.3 ± 0.5 | 20 ± 15 | 0.040 | 0.98 | 0.049 | 0.30 |
 CD14+ CD16+ | 11 ± 7.0 | 16 ± 7.3 | 4.5 ± 3.5 | 12 ± 3.1 | 0.084 |  |  |  |
Eosinophil | 76 ± 36 | 135 ± 115 | 50 ± 40 | 63 ± 45 | 0.14 |  |  |  |
Neutrophil | 4009 ± 2054 | 4329 ± 2425 | 1232 ± 688 | 1551 ± 759 | 0.013 | 0.98 | 0.073 | 0.036 |
Basophil | 30 ± 25 | 35 ± 14 | 30 ± 0.1 | 26 ± 26 | 0.90 |  |  |  |