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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: High-throughput sequencing of CD4+ T cell repertoire reveals disease-specific signatures in IgG4-related disease

Fig. 2

Coding degeneracy levels of CDR3 amino acid clonotypes. The TCR repertoires of all the individuals were downsampled to the same number of reads (158,416 TCR sequences per sample). a Distribution of coding degeneracy levels of CDR3 amino acid clonotypes. Data were represented as mean and sd. b Boxplot representing frequencies of CDR3 amino acid clonotypes with each distinct coding degeneracy level. The correlation between expansion levels and coding degeneracy levels of TCR clonotypes were analyzed by Spearman rank correlation test. c Proportion of expanded (frequency ≥ 0.01%) and coding degenerated (coding degeneracy level ≥ 2) clones in CD4+ T cell repertoire from healthy controls and IgG4-RD patients. Data were represented as mean and sd. Difference between the groups was analyzed by Welch’s t test

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