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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: High-throughput sequencing of CD4+ T cell repertoire reveals disease-specific signatures in IgG4-related disease

Fig. 4

TRBV/TRBJ gene usage and CDR3 length distribution. a Circos plot representing the 100 most frequently used TRBV-TRBJ gene combinations in CD4+ T cells from healthy controls. b Circos plot representing the 100 most frequently used TRBV-TRBJ gene combinations in CD4+ T cells from IgG4-RD patients. c Visualization of the patterns of TRBV gene usage of each individual by t-SNE dimensionality reduction analysis. d Visualization of the patterns of TRBJ gene usage of each individual by t-SNE dimensionality reduction analysis. e Visualization of the patterns of TRBV-TRBJ gene combination of each individual by t-SNE dimensionality reduction analysis. f CDR3 length distribution of CD4+ T cells from healthy controls and IgG4-RD patients. Data were represented as mean and sd

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