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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: High-throughput sequencing of CD4+ T cell repertoire reveals disease-specific signatures in IgG4-related disease

Fig. 5

Relative similarity of CD4+ T cell repertoires between individuals. a Venn diagram showing the overlap of CDR3 amino acid clonotypes identified in healthy controls and IgG4-RD patients. b Venn diagram showing the overlap of expanded CDR3 amino acid clonotypes identified in healthy controls and IgG4-RD patients. ce Multi-dimensional scaling (MDS) plot in which individuals were projected onto two-dimensional space based on pairwise TCR repertoire similarities. Relative similarity of TCR repertoires were evaluated by metric F (c), metric R (d), and metric D (e). Analysis was performed on downsampled data

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